Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation

作者：Adrien Robin, Angelique Van Ombergen, Claire Laurens, Audrey Bergouignan, Laurence Vico, Marie‐Thérèse Linossier, Anne Pavy‐Le Traon, Marc Kermorgant, Angèle Chopard, Guillaume Py, David Andrew Green, Mike Tipton, Alexander Choukèr, Pierre Denise, Hervé Normand, Stéphane Blanc, Chantal Simon, Élisabeth Rosnet, Françoise Larcher, Peter Fernández, Isabelle de Glisezinski, Dominique Larrouy, Isabelle Harant, Ines Farinha Antunes, Guillemette Gauquelin‐Koch, Marie‐Pierre Bareille, Rebecca Billette de Villemeur, Marc‐Antoine Custaud, Nastassia M. Navasiolava · 发表于：Nature Communications · 年份：2023 · DOI：10.1038/s41467-023-41990-4 · 被引用次数：35 · 研究领域：Spaceflight effects on biology、High Altitude and Hypoxia、Thermoregulation and physiological responses

Astronauts in microgravity experience multi-system deconditioning, impacting their inflight efficiency and inducing dysfunctions upon return to Earth gravity. To fill the sex gap of knowledge in the health impact of spaceflights, we simulate microgravity with a 5-day dry immersion in 18 healthy women (ClinicalTrials.gov Identifier: NCT05043974). Here we show that dry immersion rapidly induces a sedentarily-like metabolism shift mimicking the beginning of a metabolic syndrome with a drop in glucose tolerance, an increase in the atherogenic index of plasma, and an impaired lipid profile. Bone remodeling markers suggest a decreased bone formation coupled with an increased bone resorption. Fluid shifts and muscular unloading participate to a marked cardiovascular and sensorimotor deconditioning with decreased orthostatic tolerance, aerobic capacity, and postural balance. Collected datasets provide a comprehensive multi-systemic assessment of dry immersion effects in women and pave the way for future sex-based evaluations of countermeasures.