Synthesis of 3-Trifluoromethylpyrazole Derivatives

作者：Hu Ma, Danfeng Huang, Ke‐Hu Wang, Duoduo Tang, Yang Feng, Yuanyuan Reng, Junjiao Wang, Yulai Hu · 发表于：Chinese Journal of Organic Chemistry · 年份：2023 · DOI：10.6023/cjoc202302026 · 被引用次数：4 · 研究领域：Fluorine in Organic Chemistry、Synthesis and Reactions of Organic Compounds、Synthesis and Biological Evaluation

The [32] cycloaddition reactions of trifluoroacetohydrazonoyl bromides with ynones, alkynoates and aynamides have been developed, and a series of 3-trifluoromethylpyrazole derivatives were obtained in medium to excellent yields. The noble features of this protocol include excellent regioselectivity, good functional group tolerance, mild reaction conditions and simple operation. It provides an efficient and practical method for the synthesis of 3-trifluoromethylpyrazoles.