Gut microbiota and metabolomics profiles in patients with chronic stable angina and acute coronary syndrome

作者：Adilah F. Ahmad, José A. Caparrós‐Martín, Nicola Gray, Samantha Lodge, Julien Wist, Silvia Lee, Fergal O’Gara, Girish Dwivedi, Natalie C. Ward · 发表于：Physiological Genomics · 年份：2023 · DOI：10.1152/physiolgenomics.00072.2023 · 被引用次数：8 · 研究领域：Diet and metabolism studies、Gut microbiota and health、Cardiac Health and Mental Health

The study found discriminative microorganisms differentiating patients with acute coronary syndrome (ACS) from healthy controls. In addition, reduced levels of certain bacterial metabolites and elevated sCD14 and sCD163 were observed in patients with ACS compared with healthy controls. Furthermore, modified small molecule metabolomic and lipidomic signatures were found in both patient groups. Although it is not known whether these differences in profiles are associated with disease development and/or progression, the findings provide exciting options for potential new disease-related mechanism(s) and associated therapeutic target(s).