Therapeutics of osteoarthritis and pharmacological mechanisms: A focus on RANK/RANKL signaling

作者：Jingqi Liang, Liang Liu, Hui Feng, Yang Yue, Yan Zhang, Qiong Wang, Hongmou Zhao · 发表于：Biomedicine & Pharmacotherapy · 年份：2023 · DOI：10.1016/j.biopha.2023.115646 · 被引用次数：25 · 研究领域：Osteoarthritis Treatment and Mechanisms、Bone Metabolism and Diseases、Inflammatory mediators and NSAID effects

Osteoarthritis (OA) is a chronic degenerative disease afflicting millions globally. Despite the development of numerous pharmacological treatments for OA, a substantial unmet need for effective therapies persists. The RANK/RANKL signaling pathway has emerged as a promising therapeutic target for OA, owing to its pivotal role in regulating osteoclast differentiation and activity. In this comprehensive review, we aim to elucidate the relevant mechanisms of OA mediated by RANK/RANKL signaling, including bone remodeling, inflammation, cartilage degradation, osteophyte formation, and pain sensitization. Furthermore, we discuss and summarize the cutting-edge strategies targeting RANK/RANKL signaling for OA therapy, encompassing approaches such as gene-based interventions and biomaterials-aided pharmacotherapy. In addition, we highlight the prevailing challenges associated with pharmacological OA treatments and explore potential future directions, approached through a clinical-translational lens.