A nutritional supplement during preconception and pregnancy increases human milk vitamin D but not B-vitamin concentrations

作者：Soo Min Han, Fang Huang, José G. B. Derraik, Mark H. Vickers, Surabhi Devaraj, Karine Redeuil, Esther Campos-Giménez, Wei Wei Pang, Keith M. Godfrey, Shiao‐Yng Chan, Sagar K. Thakkar, Wayne S. Cutfield, Benjamin B. Albert, Shelia J. Barton, Aristea Binia, Mary Cavanagh, Hsin‐Fang Chang, Yap Seng Chong, Mary Foong‐Fong Chong, Cathryn A. Conlon, Cyrus Cooper, Paula Costello, Vanessa Cox, Christine Creagh, Marysia Depczynski, Sarah El‐Heis, Judith Hammond, Nicholas C. Harvey, Mrunalini Jagtap, Timothy Kenealy, Heidi Nield, Justin M. O’Sullivan, Gernalia Satianegara, Irma Silva-Zolezz, Shu‐E Soh, Vicky Tay, Rachael W. Taylor, Elizabeth Huiwen Tham, Philip Titcombe, Clare Wall, Ray K. Wong, Gladys Woon, Zhang Han · 发表于：Clinical Nutrition · 年份：2023 · DOI：10.1016/j.clnu.2023.09.009 · 被引用次数：14 · 研究领域：Vitamin D Research Studies、Folate and B Vitamins Research、Iron Metabolism and Disorders

Background & aims Optimal maternal vitamin status during pregnancy and lactation is essential to support maternal and infant health. For instance, vitamin D 3 is involved in infant bone development, and B-vitamins are involved in various metabolic processes, including energy production. Through a double-blind randomised controlled trial, we investigated the effects of maternal supplementation from preconception throughout pregnancy until birth on human milk (HM) concentrations of vitamin D 3 and B-vitamins. In addition, we aimed to characterise longitudinal changes in milk concentrations of these vitamins. Methods Both control and intervention supplements contained calcium, iodine, iron, β-carotene, and folic acid, while the intervention also contained zinc, vitamins B 2 , B 6 , B 12 , and D 3 , probiotics, and myo-inositol. HM samples were collected across 4 time points from 1 week to 3 months post-delivery from 158 mothers in Singapore, and 7 time points from 1 week to 12 months from 180 mothers in New Zealand. HM vitamin D was quantified using supercritical fluid chromatography and B-vitamins with mass spectrometry. Potential intervention effects on HM vitamins D 3 , B 2 , B 6 , and B 9 , as well as other B-vitamin (B 1 and B 3 ) concentrations were assessed using linear mixed models with a repeated measures design. Results Over the first 3 months of lactation, HM 25-hydroxyvitamin D 3 concentrations were 20% (95% CI 8%, 33%, P = 0.001) higher in the intervention group, wi...