Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation

作者：Muhammad Khatib, Eric T. Zhao, Shiyuan Wei, Alex Abramson, Estelle Spear Bishop, Chih‐Hsin Chen, Anne‐Laure Thomas, Chengyi Xu, Jaeho Park, Yeongjun Lee, Ryan Hamnett, Weilai Yu, Samuel E. Root, Lei Yuan, Dorine Chakhtoura, Kyun Kyu Kim, Donglai Zhong, Yuya Nishio, Chuanzhen Zhao, Can Wu, Yuanwen Jiang, Anqi Zhang, Jinxing Li, Weichen Wang, Fereshteh Salimi‐Jazi, Talha Rafeeqi, Nofar Mintz Hemed, Jeffrey B.‐H. Tok, Xiaoke Chen, Julia A. Kaltschmidt, James Dunn, Zhenan Bao · 发表于：bioRxiv (Cold Spring Harbor Laboratory) · 年份：2023 · DOI：10.1101/2023.10.02.560482 · 被引用次数：11 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Advanced Materials and Mechanics、Neurological disorders and treatments

Bioelectronic fibers hold promise for both research and clinical applications due to their compactness, ease of implantation, and ability to incorporate various functionalities such as sensing and stimulation. However, existing devices suffer from bulkiness, rigidity, limited functionality, and low density of active components. These limitations stem from the difficulty to incorporate many components on one-dimensional (1D) fiber devices due to the incompatibility of conventional microfabrication methods (e.g., photolithography) with curved, thin and long fiber structures. Herein, we introduce a fabrication approach, ‶spiral transformation″, to convert two-dimensional (2D) films containing microfabricated devices into 1D soft fibers. This approach allows for the creation of high density multimodal soft bioelectronic fibers, termed Spiral NeuroString (S-NeuroString), while enabling precise control over the longitudinal, angular, and radial positioning and distribution of the functional components. We show the utility of S-NeuroString for motility mapping, serotonin sensing, and tissue stimulation within the dynamic and soft gastrointestinal (GI) system, as well as for single-unit recordings in the brain. The described bioelectronic fibers hold great promises for next-generation multifunctional implantable electronics.