Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes

作者：Lawrence J. Appel, Morgan Erika Grams, Mark Woodward, Katie Harris, Hisatomi Arima, John Philip Chalmers, Hiroshi Yatsuya, Koji Tamakoshi, Yuanying Li, Josef Coresh, Yingying Sang, Kunihiro Matsushita, Kevan Polkinghorne, Steven James Chadban, Adeera Levin, Ognjenka Djurdjev, Mila Tang, Luxia Zhang, Fang Wang, Jinwei Wang, Ming‐Hui Zhao, Elke Schäeffner, Natalie Ebert, Nina Mielke, Marcello A. Tonelli, Anita M. Lloyd, Frank M. Sacks, Michael G. Shlipak, Nisha Bansal, Mark J. Sarnak, Kazumasa Yamagishi, Isao Muraki, Yūji Shimizu, Hiroyasu Iso, Masafumi Fukagawa, Shoichi Maruyama, Takayuki Hamano, Naohiko Fujii, Takahiro Imaizumi, Natália Alencar de Pinho, Marie Metzger, Bénédicte Stengel, Aghilès Hamroun, Ziad A. Massy, Tazeen H. Jafar, Imtiaz Jehan, Juanita Hatcher, Nish Chaturvedi, Neil R Poulter, David Collins. Wheeler, Martin Landray, Amanda Anderson, Jing Chen, James P. Lash, Jon Taliercio, Peter H Yang, Katherine R. Tuttle, Radica Alicic, Susanne B. Nicholas, Jenny I. Shen, Ben Schöttker, Hannah Stocker, Dietrich Rothenbacher, Hermann Brenner, Daniel Levy, Shih‐Jen Hwang, Markus Peter Schneider, Anna Köttgen, Heike Meiselbach, Kai‐Uwe Eckardt, Alex R. Chang, Jamie A. Green, Henry Lester Kirchner, Gurmukteshwar Singh, Simon Sawhney, Corri Black, Katie Wilde, Angharad Marks, Samira Bell, Moneeza Kalhan Siddiqui, Colin Palmer, Ewan R. Pearson, Mariko Miyazaki, Masaaki Nakayama, Tae Yamamoto, Gen Yamada, Sadayoshi Ito, Massimo Círillo, Angela Yee‐Moon Wang, Henry H. L. Wu, Hoi Ching Cheung, Victoria Ngai, Tang Ka Tak, Amit X. Garg, Eric McArthur, Ann Young, Vivekanand Jha, Ashok Kumar Yadav, Vivek Kumar, April P. Carson, Bessie A Young, Clarissa Jonas Diamantidis, Yuan‐I Min, Tanjala S. Purnell, Shizukiyo Ishikawa, Makiko Mieno, Kunihiro Yamagata, Kunitoshi Iseki, Koichi Asahi, Tsuneo Konta, Brian J. Lee, Nigel John Brunskill, Laura J. Gray, Rupert Major, James F. Medcalf, Gabriel Chodick, Cheli Melzer Cohen, Jack F.M. Wetzels, Peter J. Blankestijn, Arjan D. van Zuilen, Lesley A. Inker, Andrew S. Levey, Joachim H. Ix, Ian H. de Boer, Ronit Katz, Florian Kronenberg, Barbara Kollerits, Eberhard Ritz, Dorothea Nitsch, Girish N. Nadkarni, Lili Chan, Erwin P. Böttinger, Won-Suk Oh, Zhihong Liu, Haitao Zhang, Lihua Zhang, José Manuel Valdivielso, Marcelino Bermúdez-López, Milica Božić, Maite Caus, Juan Miguel Díaz‐Tocados, Bénédicte Stengel, Katsuyuki Miura, Hirotsugu Ueshima, Akira Okayama, Aya Kadota, Tomonori Okamura, Laura Solá, Alejandro Ferreiro, José Luis Santiago, Pablo G. Rios, Liliana Gadola, Ricardo Silvariño, Takayoshi Ohkubo, Michihiro Satoh, Hirohito Metoki, Masahiro Kikuya, Elizabeth L. Ciemins, Jeff T. Mohl, Robert G. Nelson, Robert L. Hanson, Helen C. Looker, Ron T. Gansevoort, Lyanne M. Kieneker, Stephan J. L. Bakker, Olivier Moranne, Cécile Couchoud, David J. Shepherd, Simerjot Kaur Jassal, Jaclyn Bergstrom, Csaba Pal Kovesdy, Keiichi Sumida, Prabin Shrestha, Orlando M. Gutiérrez, Katharine L. Cheung, Paul Muntner, Titilayo O. Ilori, Michelle J. Pena, Hiddo J.L. Heerspink, Edouard L. Fu, Carl‐Gustaf Elinder, Peter F. Barany, Juan Jesús Carrero, Marie Evans, Charumathi Sabanayagam, Ching‐Yu Cheng, Tien Yin Wong, C Yuen, William G. Herrington, Natalie Staplin, Martin J Landray, Colin Baigent, Philip A. Kalra, Rajkumar Chinnadurai, Darren Green, Smeeta Sinha, James P. Ritchie, Frank L.J. Visseren, Pascal Heinrich Maria Burger, M H Emmelot, Berend J. van Welzen, Oommen John, Balaji Gummidi, Arpita Ghosh, David M. J. Naimark, Navdeep Tangri, Chi-Pang Wen, Min‐Kuang Tsai, Yoshiyuki Ueno, Masafumi Watanabe, Kazunobu Ichikawa, Mohammadhassan Mirbolouk, Fereidoun Azizi, Farzad Hadaegh, Farhad Hosseinpanah, Wen Shi, Dan E. Arking, Johan Ärnlöv, Anders Olof Larsson, Vilmantas Giedraitis, Patrick Barry Mark, Jamie P. Traynor, Michael L. Sullivan, Jennifer Susan Lees, Jae Won Yang, Jae il Shin, Jun Young Lee, Jae seok Kim, Henk J.G. Bilo, Peter Ruben van Dijk, Mireille A. Edens, Joep Dille, Shoshana H. Ballew, Juan Jesús Carrero, Morgan Erika Grams, Jingsha Chen, Aditya Surapaneni, Morgan Erika Grams, Josef Coresh, Kunihiro Matsushita, Shoshana H. Ballew, Yingying Sang, Aditya Surapaneni, Natália Alencar de Pinho, Amanda Anderson, Lawrence J. Appel, Johan Ärnlöv, Fereidoun Azizi, Nisha Bansal, Samira Bell, Henk J.G. Bilo, Nigel John Brunskill, Juan Jesús Carrero, Steven James Chadban, John Philip Chalmers, Jing Chen, Elizabeth L. Ciemins, Massimo Círillo, Natalie Ebert, Marie Evans, Alejandro Ferreiro, Edouard L. Fu, Masafumi Fukagawa, Jamie A. Green, Orlando M. Gutiérrez, William G. Herrington, Shih‐Jen Hwang, Lesley A. Inker, Kunitoshi Iseki, Tazeen H. Jafar, Simerjot Kaur Jassal, Vivekanand Jha, Aya Kadota, Ronit Katz, Anna Köttgen, Tsuneo Konta, Florian Kronenberg, Brian J. Lee, Jennifer Susan Lees, Adeera Levin, Helen C. Looker, Rupert Major, Cheli Melzer Cohen, Makiko Mieno, Mariko Miyazaki, Olivier P. Moranne, Isao Muraki, David M. J. Naimark, Dorothea Nitsch, Won-Suk Oh, Michelle J. Pena, Tanjala S. Purnell, Charumathi Sabanayagam, Michihiro Satoh, Simon Sawhney, Elke Schäeffner, Ben Schöttker, Jenny I. Shen, Michael G. Shlipak, Smeeta Sinha, Bénédicte Stengel, Keiichi Sumida, Marcello A. Tonelli, José Manuel Valdivielso, Arjan D. van Zuilen, Frank L.J. Visseren, Angela Yee‐Moon Wang, Chi-Pang Wen, David Collins. Wheeler, Hiroshi Yatsuya, Kunihiro Yamagata, Jae Won Yang, Ann Young, Haitao Zhang, Luxia Zhang, Andrew S. Levey, Ron T. Gansevoort · 发表于：JAMA · 年份：2023 · DOI：10.1001/jama.2023.17002 · 被引用次数：367 · 研究领域：Chronic Kidney Disease and Diabetes、Acute Kidney Injury Research、Dialysis and Renal Disease Management

Importance: Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. Objective: To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more severe albuminuria with adverse kidney outcomes, cardiovascular outcomes, and other health outcomes. Design, Setting, and Participants: Individual-participant data meta-analysis of 27 503 140 individuals from 114 global cohorts (eGFR based on creatinine alone) and 720 736 individuals from 20 cohorts (eGFR based on creatinine and cystatin C) and 9 067 753 individuals from 114 cohorts (albuminuria) from 1980 to 2021. Exposures: The Chronic Kidney Disease Epidemiology Collaboration 2021 equations for eGFR based on creatinine alone and eGFR based on creatinine and cystatin C; and albuminuria estimated as urine albumin to creatinine ratio (UACR). Main Outcomes and Measures: The risk of kidney failure requiring replacement therapy, all-cause mortality, cardiovascular mortality, acute kidney injury, any hospitalization, coronary heart disease, stroke, heart failure, atrial fibrillation, and peripheral artery disease. The analyses were performed within each cohort and summarized with random-effects meta-analyses. Results: Within the population using eGFR based on creatinine alone (mean age, 54 years [SD, 17 years]; 51% were women; mean follow-up time, 4.8 years [SD, 3.3 years]), the mean eGFR was 90...