Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis

作者：Fen Zhang, Ting Cheng, Sheng‐Xiao Zhang · 发表于：Arthritis Research & Therapy · 年份：2023 · DOI：10.1186/s13075-023-03181-w · 被引用次数：51 · 研究领域：PI3K/AKT/mTOR signaling in cancer、Mast cells and histamine、Quinazolinone synthesis and applications

Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic synovitis and bone destruction. Proinflammatory cytokines activate pathways of immune-mediated inflammation, which aggravates RA. The mechanistic target of rapamycin (mTOR) signaling pathway associated with RA connects immune and metabolic signals, which regulates immune cell proliferation and differentiation, macrophage polarization and migration, antigen presentation, and synovial cell activation. Therefore, therapy strategies targeting mTOR have become an important direction of current RA treatment research. In the current review, we summarize the biological functions of mTOR, its regulatory effects on inflammation, and the curative effects of mTOR inhibitors in RA, thus providing references for the development of RA therapeutic targets and new drugs.