Butyrate Inhibits Dendritic Cell Activation and Alleviates Periodontitis

作者：Lili Wu, Zhenhua Luo, Yu Chen, Ziqi Yan, Jing Fu, Yiyang Jiang, Junji Xu, Ye Liu · 发表于：Journal of Dental Research · 年份：2023 · DOI：10.1177/00220345231187824 · 被引用次数：20 · 研究领域：Immunotherapy and Immune Responses、Immune Response and Inflammation、Immune cells in cancer

Dendritic cells (DCs) can mediate inflammation-related bone resorption that is crucial in the development of periodontitis. Butyrate is a critical by-product of microbes with antibacterial and anti-inflammatory properties. Here, we found that butyrate inhibited the activation of lipopolysaccharide (LPS)–induced DCs and generation of inflammatory cytokines by DCs. Moreover, butyrate regulated glycolysis in LPS-induced DCs via the G-protein-coupled receptor/hypoxia-inducible factor–1α pathway. In addition, butyrate inhibited the maturation of CD11c + MHC-II + DCs in vivo, suppressing local inflammatory infiltration and ultimately alleviating bone resorption in a periodontitis model. Our results imply that butyrate suppresses the activation of LPS-induced DCs by modulating their metabolism, highlighting its potential as a therapeutic agent for inflammatory diseases.