The epidemiology of varicella and effectiveness of varicella vaccine in Ganyu, China: a long-term community surveillance study

作者：Lingxian Qiu, Sheng Liu, Minglei Zhang, Guo‐Hua Zhong, Siying Peng, Jiali Quan, Hongyan Lin, Xiaowen Hu, Kongxin Zhu, Xingcheng Huang, Junchao Peng, Yue Huang, Shoujie Huang, Ting Wu, Jin‐Bo Xu, Zifang Dong, Qi Liang, Wei Wang, Yingying Su, Jun Zhang, Ningshao Xia · 发表于：BMC Public Health · 年份：2023 · DOI：10.1186/s12889-023-16304-4 · 被引用次数：15 · 研究领域：Herpesvirus Infections and Treatments、Sperm and Testicular Function、Ocular Diseases and Behçet’s Syndrome

BACKGROUND: The real-world data of long-term protection under moderate vaccination coverage is limited. This study aimed to evaluate varicella epidemiology and the long-term effectiveness under moderate coverage levels in Ganyu District, Lianyungang City, Jiangsu Province. METHODS: This was a population-based, retrospective birth cohort study based on the immunization information system (IIS) and the National Notifiable Disease Surveillance System (NNDSS) in Ganyu District. Varicella cases reported from 2009 to 2020 were included to describe the epidemiology of varicella, and eleven-year consecutive birth cohorts (2008-2018) were included to estimate the vaccine effectiveness (VE) of varicella by Cox regression analysis. RESULTS: A total of 155,232 native children and 3,251 varicella cases were included. The vaccination coverage was moderate with 37.1%, correspondingly, the annual incidence of varicella infection increased 4.4-fold from 2009 to 2020. A shift of the varicella cases to older age groups was observed, with the peak proportion of cases shifting from 5-6 year-old to 7-8 year-old. The adjusted effectiveness of one dose of vaccine waned over time, and the adjusted VE decreased from 72.9% to 41.8% in the one-dose group. CONCLUSIONS: The insufficient vaccination coverage (37.1%) may have contributed in part to the rising annual incidence of varicella infection, and a shift of varicella cases to older age groups occurred. The effectiveness of one dose of varicella vacci...