Multidomain interventions for non-pharmacological enhancement (MINE) program in Chinese older adults with mild cognitive impairment: a multicenter randomized controlled trial protocol

作者：Xiaochu Wu, Tianyao Zhang, Yanhao Tu, Xueling Deng, A Sigen, Yuxiao Li, Xiaofan Jing, Lixuan Wei, Ning Huang, Ying Cheng, Linghui Deng, Shuli Jia, Jun Li, Ning Jiang, Birong Dong · 发表于：BMC Neurology · 年份：2023 · DOI：10.1186/s12883-023-03390-5 · 被引用次数：3 · 研究领域：Dementia and Cognitive Impairment Research、Stroke Rehabilitation and Recovery、Mental Health and Patient Involvement

BACKGROUND: Dementia is characterized by progressive neurodegeneration and therefore early intervention could have the best chance of preserving brain health. There are significant differences in health awareness, living customs, and daily behaviors among Chinese older adults compared to Europeans and Americans. Because the synergistic benefits of multidomain non-pharmacological interventions are consistent with the multifactorial pathogenicity of MCI, such interventions are more appealing, easier to adhere to, and more relevant to daily life than single-mode interventions. One of the aims of this study is to verify the effect of multidomain intervention strategies for MCI patients based on Chinese population characteristics, and the other is to establish a biobank and image database to investigate the pathogenesis and pathways of cognitive impairment. METHODS: Our study was designed as a national multicenter, community-based randomized controlled trial (RCT). Twelve medical institutions in ten Chinese cities will participate in our study from 2020 to 2024, and 1080 community residents aged 50 and above will be enrolled as participants. Each sub-center will be responsible for 90 participants (30 people per community) across three communities (non-contact control group, health education group, and multidomain intervention group). The community will be the basic unit of the present study, and all participants in each community will receive the same intervention/control measure....