Aberrant single-subject morphological brain networks in first-episode, treatment-naive adolescents with major depressive disorder

作者：Xiaofan Qiu, Junle Li, Fen Pan, Yuping Yang, Weihua Zhou, Jinkai Chen, Ning Wei, Shaojia Lu, Xuchu Weng, Manli Huang, Jinhui Wang · 发表于：Psychoradiology · 年份：2023 · DOI：10.1093/psyrad/kkad017 · 被引用次数：20 · 研究领域：Functional Brain Connectivity Studies、Mental Health Research Topics、Neural and Behavioral Psychology Studies

Background: Neuroimaging-based connectome studies have indicated that major depressive disorder (MDD) is associated with disrupted topological organization of large-scale brain networks. However, the disruptions and their clinical and cognitive relevance are not well established for morphological brain networks in adolescent MDD. Objective: To investigate the topological alterations of single-subject morphological brain networks in adolescent MDD. Methods: Twenty-five first-episode, treatment-naive adolescents with MDD and 19 healthy controls (HCs) underwent T1-weighted magnetic resonance imaging and a battery of neuropsychological tests. Single-subject morphological brain networks were constructed separately based on cortical thickness, fractal dimension, gyrification index, and sulcus depth, and topologically characterized by graph-based approaches. Between-group differences were inferred by permutation testing. For significant alterations, partial correlations were used to examine their associations with clinical and neuropsychological variables in the patients. Finally, a support vector machine was used to classify the patients from controls. Results: Compared with the HCs, the patients exhibited topological alterations only in cortical thickness-based networks characterized by higher nodal centralities in parietal (left primary sensory cortex) but lower nodal centralities in temporal (left parabelt complex, right perirhinal ectorhinal cortex, right area PHT and right ven...