Piezoelectric materials for neuroregeneration: a review

作者：Linliang Wu, Hongxia Gao, Qi Han, Wenchao Guan, Shaolan Sun, Tiantian Zheng, Yaqiong Liu, Xiaolu Wang, Ran Huang, Guicai Li · 发表于：Biomaterials Science · 年份：2023 · DOI：10.1039/d3bm01111a · 被引用次数：62 · 研究领域：Conducting polymers and applications、Advanced Sensor and Energy Harvesting Materials、Silk-based biomaterials and applications

tissue engineering strategies is to create a microenvironment that mimics natural nerve growth for achieving functional recovery. Biomaterial scaffolds offer a promising option for the clinical treatment of large nerve gaps due to the rapid advancement of materials science and regenerative medicine. The design of biomimetic scaffolds should take into account the inherent properties of the nerve and its growth environment, such as stiffness, topography, adhesion, conductivity, and chemical functionality. Various advanced techniques have been employed to develop suitable scaffolds for nerve repair. Since neuronal cells have electrical activity, the transmission of bioelectrical signals is crucial for the functional recovery of nerves. Therefore, an ideal peripheral nerve scaffold should have electrical activity properties similar to those of natural nerves, in addition to a delicate structure. Piezoelectric materials can convert stress changes into electrical signals that can activate different intracellular signaling pathways critical for cell activity and function, which makes them potentially useful for nerve tissue regeneration. However, a comprehensive review of piezoelectric materials for neuroregeneration is still lacking. Thus, this review systematically summarizes the development of piezoelectric materials and their application in the field of nerve regeneration. First, the electrical signals and natural piezoelectricity phenomenon in various organisms are briefly intr...