Discovery of aurones bearing two amine functionalities as SHIP2 inhibitors with insulin-sensitizing effect in rat myotubes

作者：Phei Ching Lim, Beow Keat Yap, Yi Juin Tay, Nur Aziah Hanapi, Siti R. Yusof, Chong Yew Lee · 发表于：RSC Medicinal Chemistry · 年份：2023 · DOI：10.1039/d3md00360d · 被引用次数：2 · 研究领域：Protein Tyrosine Phosphatases、Synthesis and biological activity、Synthesis of Organic Compounds

An aurone bearing two amine functionalities 12a is a micromolar SHIP2 inhibitor with glucose uptake-enhancing property in rat myotubes. 12a showed good permeability across the Caco-2 cell monolayer indicating its potential as an oral insulin sensitizer.