The association of body mass index and weight waist adjustment index with serum ferritin in a national study of US adults

作者：Hao Han, Ping Ni, Siqi Zhang, Xiaojuan Ji, Mingli Zhu, Wanyu Ma, Hongfeng Ge, Hailiang Chu · 发表于：European journal of medical research · 年份：2023 · DOI：10.1186/s40001-023-01343-9 · 被引用次数：12 · 研究领域：Iron Metabolism and Disorders、Nutrition and Health in Aging、Diabetes, Cardiovascular Risks, and Lipoproteins

BACKGROUND: Abnormal serum ferritin levels are associated with a variety of diseases. Meanwhile, abnormal serum ferritin is influenced by a variety of risk factors, but its correlation with obesity remains poorly described. OBJECTIVE: This study aimed to investigate the association of body mass index (BMI) and weight waist adjustment index (WWI) with serum ferritin in US adults. METHODS: Participants in this study took part in the National Health and Nutrition Examination Survey (NHANES) prior to the pandemic from 2017 to March 2020. Serum ferritin was used as the sole response variable and BMI and WWI were used as independent variables. Multiple linear regression was used to assess the relationship between serum ferritin and the independent variables, and smoothed curve fitting and threshold effects analysis were performed to assess the presence of non-linear relationships. To validate the sensitive individuals for the correlation between the independent and the dependent variables, a subgroup analysis was performed. RESULTS: A final total of 7552 participants were included in this study. Both independent variables had a positive relationship with serum ferritin, with effect values of (β = 0.68, 95% CI: 0.17-1.19) when BMI was the independent variable and (β = 8.62, 95% CI: 3.53-13.72) when WWI was the independent variable in the fully adjusted model. This positive association between the two obesity-related indexes and serum ferritin became more significant as BMI and WWI i...