The intersection of social determinants of health, the microbiome, and health outcomes in immigrants: A scoping review

作者：Dany Fanfan, Connie J. Mulligan, Maureen Groër, Volker Mai, Michael T. Weaver, Fatma G. Huffman, Debra Lyon · 发表于：American Journal of Biological Anthropology · 年份：2023 · DOI：10.1002/ajpa.24850 · 被引用次数：11 · 研究领域：Migration, Health and Trauma、Health disparities and outcomes、Food Security and Health in Diverse Populations

In the present scoping review, we explore whether existing evidence supports the premise that social determinants of health (SDoH) affect immigrant health outcomes through their effects on the microbiome. We adapt the National Institute on Minority Health and Health Disparities' research framework to propose a conceptual model that considers the intersection of SDoH, the microbiome, and health outcomes in immigrants. We use this conceptual model as a lens through which to explore recent research about SDoH, biological factors associated with changes to immigrants' microbiomes, and long-term health outcomes. In the 17 articles reviewed, dietary acculturation, physical activity, ethnicity, birthplace, age at migration and length of time in the host country, socioeconomic status, and social/linguistic acculturation were important determinants of postmigration microbiome-related transformations. These factors are associated with progressive shifts in microbiome profile with time in host country, increasing the risks for cardiometabolic, mental, immune, and inflammatory disorders and antibiotic resistance. The evidence thus supports the premise that SDoH influence immigrants' health postmigration, at least in part, through their effects on the microbiome. Omission of important postmigration social-ecological variables (e.g., stress, racism, social/family relationships, and environment), limited research among minoritized subgroups of immigrants, complexity and inter- and intra-ind...