Insights into the associations between the gut microbiome, its metabolites, and heart failure

作者：Adilah F. Ahmad, José A. Caparrós‐Martín, Nicola Gray, Samantha Lodge, Julien Wist, Silvia Lee, Fergal O’Gara, Amit Shah, Natalie C. Ward, Girish Dwivedi · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：2023 · DOI：10.1152/ajpheart.00436.2023 · 被引用次数：15 · 研究领域：Gut microbiota and health、Clostridium difficile and Clostridium perfringens research、Diet and metabolism studies

We found a reduction in gut bacterial alpha diversity in patients with heart failure (HF) and that the stool microbiota of patients with HF was characterized by depletion of operational taxonomic units representing commensal Clostridia at both baseline and follow-up. Patients with HF also had altered bacterial metabolites and increased inflammatory profiles compared with healthy controls. A distinct metabolomic and lipidomic profile was present in patients with HF at baseline when compared with healthy controls.