Research Progress and New Perspectives of Anticancer Effects of Emodin

作者：Wu Liu, Eskandar Qaed, Yuelin Zhu, Wenzhang Tian, Yizhen Wang, Kang Le, Xiaodong Ma, Zeyao Tang · 发表于：The American Journal of Chinese Medicine · 年份：2023 · DOI：10.1142/s0192415x23500787 · 被引用次数：15 · 研究领域：Phytochemistry and biological activity of medicinal plants、Bioactive Compounds and Antitumor Agents、Chromatography in Natural Products

. Recent studies have shown that emodin exhibits potent anticancer effects against a variety of cancer types, including liver, breast, lung, and colon cancer. Emodin's anticancer effects are mediated through several mechanisms, including inhibition of cell proliferation, induction of apoptosis, and suppression of tumor angiogenesis and metastasis. In this review, we provide an overview of recent research progress and new perspectives on emodin's anticancer effect. We summarize the current understanding of the molecular mechanisms underlying emodin's anticancer activity, including its effects on signaling pathways such as the PI3K/Akt, MAPK, and NF-[Formula: see text]B pathways. We also discuss the potential of emodin as a therapeutic agent for cancer treatment, including its use in combination with conventional chemotherapeutic drugs and as a sensitizer for radiotherapy. Furthermore, we highlight recent advances in the development of emodin derivatives and their potential as novel anticancer agents. Finally, we discuss the challenges and opportunities for the translation of emodin's anticancer properties into clinical applications, including the need for further preclinical and clinical studies to evaluate its safety and efficacy. In conclusion, emodin represents a promising natural compound with potent anticancer properties, and its potential as a therapeutic agent for cancer treatment warrants further investigation. This review provides a comprehensive overview of the curre...