Associations between immune-mediated diseases (IMDs) and the risk of HPV-associated diseases: a UK Biobank cohort analysis

作者：Lan Feng, Ke Qiu, Yufang Rao, Tao Shu, Yao Song, Danni Cheng, Minzi Mao, Junhong Li, Ziyan Zhang, Xiaoyu Wang, Xinghan Zeng, Yu Zhao, Jianjun Ren · 发表于：BMJ Open · 年份：2023 · DOI：10.1136/bmjopen-2023-072249 · 被引用次数：7 · 研究领域：Cervical Cancer and HPV Research、Head and Neck Cancer Studies、Viral-associated cancers and disorders

Objectives To systematically assess the associations between various immune-mediated diseases (IMDs) and human papillomavirus (HPV)-associated diseases. Design Retrospective cohort study. Setting UK Biobank. Participants A total of 500 371 subjects aged 40–69 years were eligible for the analysis, after excluding those with prevalent HPV-associated diseases at baseline and those who had withdrawn their informed consent or lacked information on sex. Exposure Eighty IMDs (involving allergic/atopic diseases, autoimmune diseases, immunodeficiency diseases, etc) were identified in the UK Biobank. Primary and secondary outcome measures The main outcome was the incidence of HPV-associated diseases (including warts and malignancies of the cervix, oropharynx, anus, penis, vulva and vagina). Cox proportional hazards model was used to estimate HRs and 95% CIs with particular adjustment for sexual behaviours. We also conducted subgroup analyses based on benign and malignant status, and anatomical sites of HPV-associated diseases, respectively. Results During a median of 12.0 years of follow-up, 2244 cases out of 500 371 subjects developed HPV-associated diseases. Overall, participants with IMDs had a higher risk of HPV-associated diseases than their controls after adjustment for sexual behaviours and other potential confounders (female: HR=1.90, 95% CI=1.66 to 2.17, p < 0.001; male: HR=1.66, 95% CI=1.41 to 1.97, p < 0.001). Additionally, eight individual IMDs in women (eg, asthma: H...