The Dawn of a New Era: Tumor-Targeting Boron Agents for Neutron Capture Therapy

作者：Ting Luo, Wenzhi Huang, Feiyi Chu, Tianyu Zhu, Bin Feng, Shuai Huang, Jing Hou, Liyong Zhu, Shaihong Zhu, Wenbin Zeng · 发表于：Molecular Pharmaceutics · 年份：2023 · DOI：10.1021/acs.molpharmaceut.3c00701 · 被引用次数：44 · 研究领域：Boron Compounds in Chemistry、Boron and Carbon Nanomaterials Research、Radiopharmaceutical Chemistry and Applications

Cancer is widely recognized as one of the most devastating diseases, necessitating the development of intelligent diagnostic techniques, targeted treatments, and early prognosis evaluation to ensure effective and personalized therapy. Conventional treatments, unfortunately, suffer from limitations and an increased risk of severe complications. In light of these challenges, boron neutron capture therapy (BNCT) has emerged as a promising approach for cancer treatment with unprecedented precision to selectively eliminate tumor cells. The distinctive and promising characteristics of BNCT hold the potential to revolutionize the field of oncology. However, the clinical application and advancement of BNCT technology face significant hindrance due to the inherent flaws and limited availability of current clinical drugs, which pose substantial obstacles to the practical implementation and continued progress of BNCT. Consequently, there is an urgent need to develop efficient boron agents with higher boron content and specific tumor-targeting properties. Researchers aim to address this need by integrating tumor-targeting strategies with BNCT, with the ultimate goal of establishing BNCT as an effective, readily available, and cutting-edge treatment modality for cancer. This review delves into the recent advancements in integrating tumor-targeting strategies with BNCT, focusing on the progress made in developing boron agents specifically designed for BNCT. By exploring the current state o...