Evaluation of whole-brain oxygen metabolism in Alzheimer's disease using QSM and quantitative BOLD

作者：Aocai Yang, Hangwei Zhuang, Lei Du, Bing Liu, Kuan Lv, Jixin Luan, Pianpian Hu, Feng Chen, Kai Wu, Ni Shu, Amir Shmuel, Guolin Ma, Yi Wang · 发表于：NeuroImage · 年份：2023 · DOI：10.1016/j.neuroimage.2023.120381 · 被引用次数：20 · 研究领域：Advanced MRI Techniques and Applications、Advanced Neuroimaging Techniques and Applications、Functional Brain Connectivity Studies

The objective of this study was to evaluate the whole-brain pattern of oxygen extraction fraction (OEF), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen consumption (CMRO2) perturbation in Alzheimer's disease (AD) and investigate the relationship between regional cerebral oxygen metabolism and global cognition. Twenty-six AD patients and 25 age-matched healthy controls (HC) were prospectively recruited in this study. Mini-Mental State Examination (MMSE) was used to evaluate cognitive status. We applied QQ-CCTV algorithm which combines quantitative susceptibility mapping and quantitative blood oxygen level-dependent models (QQ) for OEF calculation. CBF map was computed from arterial spin labeling and CMRO2 was generated based on Fick's principle. Whole-brain and regional OEF, CBF, and CMRO2 analyses were performed. The associations between these measures in substructures of deep brain gray matter and MMSE scores were assessed. Whole brain voxel-wise analysis showed that CBF and CMRO2 values significantly decreased in AD predominantly in the bilateral angular gyrus, precuneus gyrus and parieto-temporal regions. Regional analysis showed that CBF value decreased in the bilateral caudal hippocampus and left rostral hippocampus and CMRO2 value decreased in left caudal and rostral hippocampus in AD patients. The mean CBF and CMRO2 values in the bilateral hippocampus positively correlated with the MMSE score over the AD and HC groups combined. CMRO2 mapping with the ...