Antibacterial oxygenated ergostane-type steroids produced by the marine sponge-derived fungus Aspergillus sp.

作者：Huimin Wen, Ya‐Wen Zhang, Fangjian Feng, Guobao Huang, Yu-Han Lv, Zou-Yan Zhang, Lijian Ding · 发表于：Journal of Asian Natural Products Research · 年份：2023 · DOI：10.1080/10286020.2023.2259317 · 被引用次数：9 · 研究领域：Marine Sponges and Natural Products、Microbial Natural Products and Biosynthesis、Fungal Biology and Applications

Two oxygenated ergostane-type steroids including one new compound, 3β-hydroxy-5α,6β-methoxyergosta-7,22-dien-15-one (1) along with a known analogue ergosta-6,22-dien-3β,5α,8α-triol (2) were isolated from the crude extracts of the marine sponge-derived fungus Aspergillus sp. Their structures were elucidated on the basis of combined NMR and MS spectroscopic methods. Compound 1 was a marine ergostane-type steroid with two methoxy groups at C-5 and C-6, respectively. These oxygenated ergostane-type steroids were evaluated for their antibacterial activities against human or aquatic pathogens. Among them, compound 1 exhibited antibacterial activity against Staphylococcus aureus.