Comparison of eltrombopag and avatrombopag in the treatment of refractory/relapsed aplastic anemia: a single-center retrospective study in China

作者：Zhuxin Zhang, Qinglin Hu, Chen Yang, Miao Chen, Bing Han · 发表于：Therapeutic Advances in Hematology · 年份：2023 · DOI：10.1177/20406207231191310 · 被引用次数：13 · 研究领域：Platelet Disorders and Treatments、Hematopoietic Stem Cell Transplantation、Complement system in diseases

Background: Eltrombopag (ELT), a thrombopoietin receptor agonist (TPO-RA), has been approved for relapsed/refractory aplastic anemia (AA). However, data on avatrombopag (AVA), another TPO-RA, are limited, and the comparisons between the two TPO-RAs are lacking. Objectives: We aimed to compare the efficacy and safety between ELT and AVA in relapsed/refractory AA patients. Design: In this retrospective study, patients with relapsed/refractory AA who had been treated with ELT ( N = 45) or AVA ( N = 30) alone and had compatible baseline hematological parameters were compared. Methods: Data from patients diagnosed with acquired AA were retrospectively collected. All patients were refractory/relapsed to standard immunosuppressive therapy (IST) for at least 6 months before ELT or AVA. Patients had to be treated with ELT or AVA alone for at least 6 months before evaluation if they did not respond. Baseline characteristics, overall response (OR), complete response (CR), relapse, adverse events, and factors that may affect efficacy were analyzed. Results: Of the 75 patients enrolled, 45 received ELT and 30 received AVA. Patients with AVA had a higher percentage of abnormal liver or renal function than those with ELT ( p = 0.036). No significant difference was found in the OR/CR rate in the first/second/third/sixth month between the two cohorts ( p > 0.05). Patients treated with AVA had a shorter median time to response than those treated with ELT ( p = 0.012) and had a higher platelet ...