Global prevalence of asymptomatic norovirus infection in outbreaks: a systematic review and meta-analysis

作者：Jun Wang, Zhao Gao, Zurong Yang, Kun Liu, Hui Zhang · 发表于：BMC Infectious Diseases · 年份：2023 · DOI：10.1186/s12879-023-08519-y · 被引用次数：24 · 研究领域：Viral gastroenteritis research and epidemiology、Respiratory viral infections research、Clostridium difficile and Clostridium perfringens research

Abstract Background Although many studies on asymptomatic norovirus infection in outbreaks have been conducted globally, structured data (important for emergency management of outbreaks) on the prevalence of this epidemic are still not available. This study assessed the global prevalence of asymptomatic norovirus infection in outbreaks. Methods We identified publications on asymptomatic infections from norovirus outbreaks by searching the PubMed, Embase, Cochrane Library, Medline, and Web of Science databases and screening references from the articles reviewed. Prevalence of asymptomatic norovirus infection in outbreaks was employed as the primary summary data. The random-effects model of the meta-analysis was fitted to generate estimates of the prevalence in the overall and subgroup populations. Results In total, 44 articles with a sample size of 8,115 asymptomatic individuals were included. The estimated pooled prevalence of asymptomatic norovirus infection in outbreaks was 21.8% (95%CI, 17.4–27.3). The asymptomatic prevalence of norovirus GII (20.1%) was similar to that of GI (19.8%); however, the proportion prevalence of asymptomatic individuals involved in the former (33.36%) was significantly higher than that of in the latter (0.92%) and the former (93.18%) was reported much more frequently than the latter (15.91%) in the included articles. These studies had significant heterogeneity (I 2 = 92%, τ 2 = 0.4021, P < 0.01). However, the source of heterogeneity could not ...