Abnormal blood microbiota profiles are associated with inflammation and immune restoration in HIV/AIDS individuals

作者：Xiaoyan Guo, Zerui Wang, Mengmeng Qu, Yuntian Guo, Minrui Yu, Weiguo Hong, Chao Zhang, Xing Fan, Jin‐Wen Song, Ruonan Xu, Ji‐Yuan Zhang, Huihuang Huang, Enqiang Linghu, Fu‐Sheng Wang, Lijun Sun, Yan‐Mei Jiao · 发表于：mSystems · 年份：2023 · DOI：10.1128/msystems.00467-23 · 被引用次数：24 · 研究领域：HIV Research and Treatment、Gut microbiota and health、Clostridium difficile and Clostridium perfringens research

ABSTRACT Although gut microbiota alteration and related blood microbe profiles in human immunodeficiency virus (HIV)-infected individuals are associated with the disease progression, how abnormal blood microbe profiles influence the inflammation and immune restoration are not fully understood. To address these issues, this study enrolled 24 healthy controls (HCs) and 91 HIV-infected individuals, including 30 treatment-naïve individuals (TNs), 31 immunological non-responders (INRs), and 30 immunological responders (IRs); subsequently, we analyzed blood microbe profiles using metagenomic sequencing and Olink proteomics technology, and identify inflammation-related proteins in peripheral blood samples of these individuals. The results showed increased translocation of microbes in the blood of TNs. This translocation did not return to normal level in either IRs or INRs who received antiretroviral therapy. In addition, Porphyromonas gingivalis significantly increased in TNs, IRs, and INRs compared to HCs. P. gingivalis was inversely associated with CD4 + T-cell counts, CD4/CD8 ratio, latency-associated peptide transforming growth factor-β1, and tumor necrosis factor-related activation-induced cytokine (TRANCE) and positively associated with HIV reservoirs. Burkholderia multivorans and Bacillus thuringiensis significantly decreased in TNs, IRs, and INRs compared to HCs and were positively associated with CD4 + T-cell counts and the CD4/CD8 ratio and negatively associated with HIV r...