Engineered Exosomes as Theranostic Platforms for Cancer Treatment

作者：Xu Yang, Xiangyu Xie, Songbin Liu, Wei Ma, Zhi Zheng, Hua Wei, Cui‐Yun Yu · 发表于：ACS Biomaterials Science & Engineering · 年份：2023 · DOI：10.1021/acsbiomaterials.3c00745 · 被引用次数：14 · 研究领域：Extracellular vesicles in disease、Nanoplatforms for cancer theranostics、RNA Interference and Gene Delivery

Tremendous progress in nanotechnology and nanomedicine has made a significant positive effect on cancer treatment by integrating multicomponents into a single multifunctional nanosized delivery system for combinatorial therapies. Although numerous nanocarriers developed so far have achieved excellent therapeutic performance in mouse models via elegant integration of chemotherapy, photothermal therapy, photodynamic therapy, sonodynamic therapy, and immunotherapy, their synthetic origin may still cause systemic toxicity, immunogenicity, and preferential detection or elimination by the immune system. Exosomes, endogenous nanosized particles secreted by multiple biological cells, could be absorbed by recipient cells to facilitate intercellular communication and content delivery. Therefore, exosomes have emerged as novel cargo delivery tools and attracted considerable attention for cancer diagnosis and treatment due to their innate stability, biological compatibility, and biomembrane penetration capacity. Exosome-related properties and functions have been well-documented; however, there are few reviews, to our knowledge, with a focus on the combination of exosomes and nanotechnology for the development of exosome-based theranostic platforms. To make a timely review on this hot subject of research, we summarize the basic information, isolation and functionalization methodologies, diagnostic and therapeutic potential of exosomes in various cancers with an emphasis on the description...