Home‐based exergaming to treat gait and balance disorders in patients with Parkinson's disease: A phase II randomized controlled trial

作者：Dijana Nuic, Sjors C.F. van de Weijer, Saoussen Cherif, Anna Skrzatek, Eline Zeeboer, Claire Olivier, Jean‐Christophe Corvol, Pierre Foulon, Jénica Pastor, Grégoire Mercier, Brian Lau, Bastiaan R. Bloem, Nienke M. de Vries, Marie‐Laure Welter · 发表于：European Journal of Neurology · 年份：2023 · DOI：10.1111/ene.16055 · 被引用次数：28 · 研究领域：Balance, Gait, and Falls Prevention、Parkinson's Disease Mechanisms and Treatments、Parkinson's Disease and Spinal Disorders

BACKGROUND: Exergaming has been proposed to improve gait and balance disorders in Parkinson's disease (PD) patients. We aimed to assess the efficacy of a home-based, tailored, exergaming training system designed for PD patients with dopa-resistant gait and/or balance disorders in a controlled randomized trial. METHODS: We recruited PD patients with dopa-resistant gait and/or balance disorders. Patients were randomly assigned (1:1 ratio) to receive 18 training sessions at home by playing a tailored exergame with full-body movements using a motion capture system (Active group), or by playing the same game with the computer's keyboard (Control group). The primary endpoint was the between-group difference in the Stand-Walk-Sit Test (SWST) duration change after training. Secondary outcomes included parkinsonian clinical scales, gait recordings, and safety. RESULTS: Fifty PD patients were enrolled and randomized. After training, no significant difference in SWST change was found between groups (mean change SWST duration [SD] -3.71 [18.06] s after Active versus -0.71 [3.41] s after Control training, p = 0.61). Some 32% of patients in the Active and 8% in the Control group were considered responders to the training program (e.g., SWST duration change ≥2 s, p = 0.03). The clinical severity of gait and balance disorders also significantly decreased after Active training, with a between-group difference in favor of the Active training (p = 0.0082). Home-based training induced no serious...