Aberrant resting‐state functional connectivity underlies cognitive and functional impairments in remitted patients with bipolar disorder

作者：Lydia Fortea, Alexander Tobias Ysbæk-Nielsen, Julian Macoveanu, Jeff Zarp Petersen, Patrick M. Fisher, Lars Vedel Kessing, Gitte M. Knudsen, Joaquim Raduà, Eduard Vieta, Kamilla Woznica Miskowiak · 发表于：Acta Psychiatrica Scandinavica · 年份：2023 · DOI：10.1111/acps.13615 · 被引用次数：17 · 研究领域：Bipolar Disorder and Treatment、Functional Brain Connectivity Studies、Mental Health Research Topics

BACKGROUND: Bipolar disorder (BD) is commonly associated with cognitive impairments, that directly contribute to patients' functional disability. However, there is no effective treatment targeting cognition in BD. A key reason for the lack of pro-cognitive interventions is the limited insight into the brain correlates of cognitive impairments in these patients. This is the first study investigating the resting-state neural underpinnings of cognitive impairments in different neurocognitive subgroups of patients with BD. METHOD: Patients with BD in full or partial remission and healthy controls (final sample of n = 144 and n = 50, respectively) underwent neuropsychological assessment and resting-state functional magnetic resonance imaging. We classified the patients into cognitively impaired (n = 83) and cognitively normal (n = 61) subgroups using hierarchical cluster analysis of the four cognitive domains. We used independent component analysis (ICA) to investigate the differences between the neurocognitive subgroups and healthy controls in resting-state functional connectivity (rsFC) in the default mode network (DMN), executive central network (ECN), and frontoparietal network (FPN). RESULTS: Cognitively impaired patients displayed greater positive rsFC within the DMN and less negative rsFC within the ECN than healthy controls. Across cognitively impaired patients, lower positive connectivity within DMN and lower negative rsFC within ECN correlated with worse global cognitive...