Fluoroalkylation of Activated Allylic Acetates through Radical–Radical Coupling: Organophotoredox/DABCO Catalytic System

作者：Xiaoyu Zhang, Yinlei Zhang, Xiaohong Li, Bowen Li, Shiji Xiao, Yongming Tang, Peizhong Xie, Teck‐Peng Loh · 发表于：Organic Letters · 年份：2023 · DOI：10.1021/acs.orglett.3c02456 · 被引用次数：16 · 研究领域：Fluorine in Organic Chemistry、Radical Photochemical Reactions、Catalytic C–H Functionalization Methods

A novel organophotoredox/DABCO catalytic system for the fluoroalkylation of activated allylic acetates via radical-radical coupling is described. The method offers mild reaction conditions, high selectivity, and broad substrate compatibility and enabled diverse bioactive molecules, FDA-approved drugs, and amino acid derivatives to be incorporated into transformation. This study expands the synthetic toolbox for the construction of fluorine-containing molecules.