Updated Management of Colorectal Cancer Liver Metastases: Scientific Advances Driving Modern Therapeutic Innovations

作者：Ranish K. Patel, Shahrose Rahman, Issac R. Schwantes, Alexandra Q. Bartlett, Robert L Eil, Khashayar Farsad, Kathryn Jane Fowler, Shaun M. Goodyear, Lissi Hansen, Adel Kardosh, Nima Nabavizadeh, Flavio G. Rocha, Vassiliki Liana Tsikitis, Melissa Hirose Wong, Skye C. Mayo · 发表于：Cellular and Molecular Gastroenterology and Hepatology · 年份：2023 · DOI：10.1016/j.jcmgh.2023.08.012 · 被引用次数：49 · 研究领域：Colorectal Cancer Treatments and Studies、Hepatocellular Carcinoma Treatment and Prognosis、Cancer Genomics and Diagnostics

Colorectal cancer is the second leading cause of cancer-related deaths in the United States and accounts for an estimated 1 million deaths annually worldwide. The liver is the most common site of metastatic spread from colorectal cancer, significantly driving both morbidity and mortality. Although remarkable advances have been made in recent years in the management for patients with colorectal cancer liver metastases, significant challenges remain in early detection, prevention of progression and recurrence, and in the development of more effective therapeutics. In 2017, our group held a multidisciplinary state-of-the-science symposium to discuss the rapidly evolving clinical and scientific advances in the field of colorectal liver metastases, including novel early detection and prognostic liquid biomarkers, identification of high-risk cohorts, advances in tumor-immune therapy, and different regional and systemic therapeutic strategies. Since that time, there have been scientific discoveries translating into therapeutic innovations addressing the current management challenges. These innovations are currently reshaping the treatment paradigms and spurring further scientific discovery. Herein, we present an updated discussion of both the scientific and clinical advances and future directions in the management of colorectal liver metastases, including adoptive T-cell therapies, novel blood-based biomarkers, and the role of the tumor microbiome. In addition, we provide a comprehe...