Intraosseous Spindle Cell Rhabdomyosarcoma with MEIS1 :: NCOA2 Fusion – Case Report with Substantial Clinical Follow-up and Review of the Literature

作者：Benjamin F. Smith, Yee-Cheen Doung, Brooke Beckett, Christopher L. Corless, Lara E. Davis, Jessica L. Davis · 发表于：Cancer Investigation · 年份：2023 · DOI：10.1080/07357907.2023.2255668 · 被引用次数：14 · 研究领域：Sarcoma Diagnosis and Treatment、Tumors and Oncological Cases、Medical Imaging and Pathology Studies

Spindle cell/sclerosing rhabdomyosarcoma (SSRMS) is a clinicopathologically and molecularly heterogeneous disease. Gene fusions have been identified in intraosseous SSRMS, consisting predominantly of EWSR1/FUS::TFCP2 and MEIS1::NCOA2. The former often follow an aggressive clinical course; there is limited clinical follow-up available for the latter. We report here a new case of the very rare intraosseous SSRMS with MEIS1::NCOA2 gene fusion and include the detailed treatment course and 52 months of clinical follow-up. SSRMS with MEIS1::NCOA2 gene fusion appears biologically distinct from other intraosseous SSRMS, following a course characterized by local recurrence with rare reports of metastasis to date.