Evolution and distribution of rabies viruses from a panorama view

作者：Gen Li, Yue Zhang, He Hongling, Changyi Chen, Xin Li, Yu Xiao, Zhibin Yan, Ying‐Hao Chu, Jun Luo, Xiaofeng Guo · 发表于：Microbiology Spectrum · 年份：2023 · DOI：10.1128/spectrum.05257-22 · 被引用次数：3 · 研究领域：Rabies epidemiology and control、Poxvirus research and outbreaks、Microbial infections and disease research

ABSTRACT Rabies kills more than 59,000 people annually, mainly in developing countries. Previous studies on the evolution and distribution of rabies viruses (RABVs) were scattered. Here, we explore the evolution and distribution of this deadly virus from a novel panorama view. Multiple bioinformatic software tools were employed to analyze the phylogenetic diversity, evolution, spatiotemporal, and distribution of RABVs. The analyses were based on 1,202 qualified full-length genomes of RABVs and numerous literatures. Of the 10 distinct phylogenetic clades of RABV that we identified, more frequent intra- and inter-clade recombination occurs in the sequences of Asian-SEA, Arctic, and Cosmopolitan clades isolated from China, while according to existing sequence information, RABV might originate from bats (posterior probability, PP = 0.75, PP = 0.60 inferred from N and L genes, separately) in North America (PP = 0.57, PP = 0.62 inferred from N and L genes, separately). Due to the difference in evolutionary rate of N (2.22 × 10 −4 subs/site/year, 95% HPD 1.99–2.47 × 10 −4 subs/site/year) and L genes (1.67 × 10 −4 subs/site/year, 95% HPD 1.59–1.74 × 10 −4 subs/site/year), the root age was 1,406.6 (95% HPD 1,291.2–1,518.2) and 1,122.7 (95% HPD 1,052.4–1,193.9) inferred from N and L genes, separately. Among other findings, Mephitidae plays an important role in the interspecific transmission and communication of RABV, which we found tends to spread to populations genetically proximate t...