Association of Device-Measured Physical Activity With Cardiovascular Outcomes in Individuals With Hypertension

作者：Boyang Xiang, Yujia Zhou, Xiaoguang Wu, Xiang Zhou · 发表于：Hypertension · 年份：2023 · DOI：10.1161/hypertensionaha.123.21663 · 被引用次数：31 · 研究领域：Physical Activity and Health、Cardiovascular and exercise physiology、Mobile Health and mHealth Applications

BACKGROUND: There is insufficient evidence to show that the guidelines' recommendations of physical activity (PA) are associated with long-term benefits in individuals with hypertension. METHODS: This prospective cohort study included UK Biobank participants with hypertension. Time spent on vigorous-intensity PA (VPA), moderate-intensity PA (MPA), and light-intensity PA (LPA) measured by wrist-worn accelerometer were extracted. The primary outcomes were major adverse cardiovascular events (including cardiovascular death, stroke, and myocardial infarction) and all-cause mortality. The secondary outcomes were cardiovascular death, myocardial infarction, and stroke, respectively. The relationships of PA with outcomes were analyzed using Cox regression models. RESULTS: This study included 49 060 eligible participants with a median follow-up of 7.0 years. MPA was inversely associated with risks of major adverse cardiovascular events and all-cause mortality. Modest amounts of LPA or VPA were likely to be more beneficial than higher amounts of either in all-cause death or cardiovascular outcomes. Compared with the least active group, 150 to 300 min/wk of MPA or more was significantly associated with decreased risk of all-cause death (by 34%-54%) and major adverse cardiovascular events (by 23%-41%), but 75 to 150 min/wk of VPA or more was associated with few further benefits, even weakening the cardiovascular benefits. CONCLUSIONS: MPA had an inverse dose-response association with th...