Regulation of anoikis by extrinsic death receptor pathways

作者：Ying‐Hao Han, Yuan Wang, Seung‐Jae Lee, Meihua Jin, Hu‐Nan Sun, Taeho Kwon · 发表于：Cell Communication and Signaling · 年份：2023 · DOI：10.1186/s12964-023-01247-5 · 被引用次数：84 · 研究领域：Cell death mechanisms and regulation、Endoplasmic Reticulum Stress and Disease、PARP inhibition in cancer therapy

Metastatic cancer cells can develop anoikis resistance in the absence of substrate attachment and survive to fight tumors. Anoikis is mediated by endogenous mitochondria-dependent and exogenous death receptor pathways, and studies have shown that caspase-8-dependent external pathways appear to be more important than the activity of the intrinsic pathways. This paper reviews the regulation of anoikis by external pathways mediated by death receptors. Different death receptors bind to different ligands to activate downstream caspases. The possible mechanisms of Fas-associated death domain (FADD) recruitment by Fas and TNF receptor 1 associated-death domain (TRADD) recruitment by tumor necrosis factor receptor 1 (TNFR1), and DR4- and DR5-associated FADD to induce downstream caspase activation and regulate anoikis were reviewed. This review highlights the possible mechanism of the death receptor pathway mediation of anoikis and provides new insights and research directions for studying tumor metastasis mechanisms. Video Abstract.