NORMAN guidance on suspect and non-target screening in environmental monitoring

作者：Juliane Hollender, Emma Schymanski, Lutz Ahrens, ‪Nikiforos Alygizakis, Frederic Béen, Lubertus Bijlsma, Andrea M. Brunner, Alberto Celma, Aurélie Fildier, Qiuguo Fu, Pablo Gago-Ferrero, Rubén Gil‐Solsona, Peter Haglund, Martin Hansen, Sarit Kaserzon, Anneli Kruve, M.H. Lamoree, C. Margoum, Jeroen Meijer, Sylvain Merel, Cassandra Rauert, Paweł Rostkowski, Saer Samanipour, Bastian Schulze, Tobias Schulze, Randolph R. Singh, Jaroslav Slobodnı́k, Teresa Mairinger, Νikolaos S. Τhomaidis, Anne Togola, Katrin Vorkamp, Emmanuelle Vulliet, Linyan Zhu, Martin Krauß · 发表于：Environmental Sciences Europe · 年份：2023 · DOI：10.1186/s12302-023-00779-4 · 被引用次数：271 · 研究领域：Metabolomics and Mass Spectrometry Studies、Atmospheric and Environmental Gas Dynamics、Isotope Analysis in Ecology

Abstract Increasing production and use of chemicals and awareness of their impact on ecosystems and humans has led to large interest for broadening the knowledge on the chemical status of the environment and human health by suspect and non-target screening (NTS). To facilitate effective implementation of NTS in scientific, commercial and governmental laboratories, as well as acceptance by managers, regulators and risk assessors, more harmonisation in NTS is required. To address this, NORMAN Association members involved in NTS activities have prepared this guidance document, based on the current state of knowledge. The document is intended to provide guidance on performing high quality NTS studies and data interpretation while increasing awareness of the promise but also pitfalls and challenges associated with these techniques. Guidance is provided for all steps; from sampling and sample preparation to analysis by chromatography (liquid and gas—LC and GC) coupled via various ionisation techniques to high-resolution tandem mass spectrometry (HRMS/MS), through to data evaluation and reporting in the context of NTS. Although most experience within the NORMAN network still involves water analysis of polar compounds using LC–HRMS/MS, other matrices (sediment, soil, biota, dust, air) and instrumentation (GC, ion mobility) are covered, reflecting the rapid development and extension of the field. Due to the ongoing developments, the different questions addressed with NTS and manifold ...