Causal relationships between CD25 on immune cells and hip osteoarthritis

作者：Hao Luo, Yong Zhu, Bin Guo, Zhe Ruan, Zhi Long Liu, Zhihua Fan, Shushan Zhao · 发表于：Frontiers in Immunology · 年份：2023 · DOI：10.3389/fimmu.2023.1247710 · 被引用次数：23 · 研究领域：Osteoarthritis Treatment and Mechanisms、Rheumatoid Arthritis Research and Therapies、Genetic Associations and Epidemiology

Objectives Previous research has indicated a potential association between immune factors and osteoarthritis (OA), but the causal relationship between CD25 expression on immune cells and hip OA remains enigmatic. To shed light on this relationship, this study utilized the two-sample Mendelian Randomization (MR) method. Methods Leveraging genome-wide association studies (GWAS) data from the UK Biobank and arcOGEN, the investigation encompasses a substantial European cohort comprising 15,704 hip OA cases and 378,169 controls. Genetic insights into CD25 stem from a subgroup of 3,757 individuals with European ancestry, encompassing 77 CD25-related traits. Several MR methods were applied, and robustness was assessed through heterogeneity and sensitivity analysis. Results Among the 77 traits examined, 66 shared the same single nucleotide polymorphisms (SNPs) with hip OA. Of these, 7 CD25-related traits were found to be causally associated with hip OA (adjusted P ><0.05), with F-statistics ranging from 33 to 122. These traits are specifically related to CD4 + CD25 + T cells, exhibiting odds ratios (OR) and 95% confidence intervals (CI) less than 1. Notably, no causal link was discerned with the CD8+CD25+ T cell subset. Within absolute count (AC) and relative count (RC) trait types, a significant causal relationship was observed solely between CD4 + CD25 + T cells and hip OA, without subtype localization. A more intricate examination of CD25 expression levels within the...