A Dual‐Antioxidative Coating on Transmucosal Component of Implant to Repair Connective Tissue Barrier for Treatment of Peri‐Implantitis

作者：Dize Li, Xi Tan, Liwen Zheng, Han Tang, Shanshan Hu, Qiming Zhai, Xuan Jing, Panpan Liang, Yuxin Zhang, Qingqing He, Guangyu Jian, Dongqi Fan, Ping Ji, Tao Chen, Hongmei Zhang · 发表于：Advanced Healthcare Materials · 年份：2023 · DOI：10.1002/adhm.202301733 · 被引用次数：25 · 研究领域：Dental Implant Techniques and Outcomes、Oral and gingival health research、Bone Tissue Engineering Materials

Abstract Since the microgap between implant and surrounding connective tissue creates the pass for pathogen invasion, sustained pathological stimuli can accelerate macrophage‐mediated inflammation, therefore affecting peri‐implant tissue regeneration and aggravate peri‐implantitis. As the transmucosal component of implant, the abutment therefore needs to be biofunctionalized to repair the gingival barrier. Here, a mussel‐bioinspired implant abutment coating containing tannic acid (TA), cerium and minocycline (TA‐Ce‐Mino) is reported. TA provides pyrogallol and catechol groups to promote cell adherence. Besides, Ce 3+ /Ce 4+ conversion exhibits enzyme‐mimetic activity to remove reactive oxygen species while generating O 2 , therefore promoting anti‐inflammatory M2 macrophage polarization to help create a regenerative environment. Minocycline is involved on the TA surface to create local drug storage for responsive antibiosis. Moreover, the underlying therapeutic mechanism is revealed whereby the coating exhibits exogenous antioxidation from the inherent properties of Ce and TA and endogenous antioxidation through mitochondrial homeostasis maintenance and antioxidases promotion. In addition, it stimulates integrin to activate PI3K/Akt and RhoA/ROCK pathways to enhance VEGF‐mediated angiogenesis and tissue regeneration. Combining the antibiosis and multidimensional orchestration, TA‐Ce‐Mino repairs soft tissue barriers and effector cell differentiation, thereby isolating the imm...