Impact of visceral obesity on infectious complications after resection for colorectal cancer: a retrospective cohort study

作者：Wenshan Zhai, Yi Yang, Keyao Zhang, Lei Sun, Meng Luo, Xue Han⊗, Min Wang, Zhiping Wang, Fang Gao · 发表于：Lipids in Health and Disease · 年份：2023 · DOI：10.1186/s12944-023-01890-4 · 被引用次数：13 · 研究领域：Nutrition and Health in Aging、Colorectal Cancer Surgical Treatments、Inflammatory Biomarkers in Disease Prognosis

OBJECTIVES: To explore the impact of visceral obesity (VO) measured by preoperative abdominal computed tomography (CT) on postoperative infectious complications for colorectal cancer (CRC) patients and establish a predictive model. METHODS: Patients who underwent resection for colorectal cancer between January 2015 and January 2021 were enrolled in this study. All patients were measured for body mass index (BMI) and visceral fat area (VFA) preoperatively. Infectious complications were compared between the different groups according to BMI and VO categories. Univariate and multivariate logistic regression were used to analyze whether VO was an independent risk factor for postoperative infectious complications. According to the results of logistic regression, six machine learning approaches were used to establish predictive models and perform internal validation. The best-performing model was interpreted by the SHAPley Additive exPlanations value. RESULTS: Approximately 64.81% of 520 patients had VO. VO was significantly connected with postoperative infectious complications (P < 0.001), coronary heart disease (P = 0.004), cerebral infarction (P = 0.001), hypertension (P < 0.001), diabetes (P < 0.001), and fatty liver (P < 0.001). The rates of wound infection (P = 0.048), abdominal or pelvic infection (P = 0.006), and pneumonia (P = 0.008) increased obviously in patients with VO. Compared to the low BMI group, a high BMI was found to be significantly associated with hypertension...