Association between tea consumption and colorectal cancer: a systematic review and meta-analysis of a population-based study

作者：Yu Huang, Qiang Chen, Yating Liu, Ruoxi Tian, Yin Xu, Yaoguang Hao, Yang Yang, Jian Yang, Zongxuan Li, Suyang Yu, Hongyan Li, Guiying Wang · 发表于：BMC Gastroenterology · 年份：2023 · DOI：10.1186/s12876-023-02928-8 · 被引用次数：10 · 研究领域：Tea Polyphenols and Effects、Heavy Metals in Plants、Nutritional Studies and Diet

PURPOSE: A meta-analysis study was performed to systematically assess the association between tea consumption and CRC risk. METHODS: Cochrane Library, Embase, PubMed, and Web of Science were retrieved to collect articles in English since 24 July 2023. Databases were searched and evaluated by two reviewers independently.We screened the literature based on inclusion and exclusion criteria. After determining the random effect model or fixed utility model based on a heterogeneity test, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS: We included fourteen articles in this meta-analysis. We analyzed the data using a random effect model to explore the association between tea consumption and CRC because of apparent heterogeneity (P < 0.001, I2 = 99.5%). The combined results of all tests showed that there is no statistically significant association between tea consumption and CRC risk (OR = 0.756, 95%CI = 0.470-1.215, P = 0.247). Subsequently, subgroup analysis and sensitivity analysis were performed. Excluding any single study, the overall results ranged from 0.73 (95%CI = 0.44-1.20) to 0.86 (95%CI = 0.53-1.40). It was determined that there was no significant publication bias between tea consumption and CRC risk (P = 0.064) by Egger's tests. CONCLUSIONS: The results indicated that tea consumption may not be significantly associated with the development of CRC. IMPLICATIONS OF KEY FINDINGS: Tea reduces colon cancer risk by 24%, but the estimate is uncerta...