Association of vitamin B1 with cardiovascular diseases, all-cause and cardiovascular mortality in US adults

作者：Wen He, Xiaona Niu, Ran Zhao, Qiuhe Wang, Nan Sun, Le Ma, Yan Li, Wei Zhang · 发表于：Frontiers in Nutrition · 年份：2023 · DOI：10.3389/fnut.2023.1175961 · 被引用次数：21 · 研究领域：Vitamin K Research Studies、Folate and B Vitamins Research、Alcoholism and Thiamine Deficiency

Background: The correlation between dietary vitamin B1 intake and cardiovascular diseases, as well as the all-cause and cardiovascular-associated mortality, is not well known. A large-scale data pool was used to examine the aforementioned correlations of Vitamin B1. Methods: This paper analyzed the dietary data from the survey conducted by National Health and Nutrition Examination (NHANES; 1999-2018). The correlation of vitamin B1 intake in each quartile with cardiovascular diseases such as hypertension, coronary heart disease, myocardial infarction and heart failure was analyzed using multivariate logistic regression models. The hazard ratios for dietary vitamin B1 intake in each quartile, along with all-cause and cardiovascular-associated mortality, were performed using multivariate cox regression analysis, setting the lowest quartile (Q1) as a reference. The restricted cubic spline (RCS) method was used to study the nonlinear relationship. Subgroup stratification and sensitivity analyses were used to further investigate the association between them. Results: The study enrolled 27,958 subjects (with a mean follow-up time of 9.11 years). After multivariate adjustment, dietary vitamin B1 intake was significantly associated with hypertension, heart failure and cardiovascular mortality, with the most significant association in quartile 4 (Q4) of vitamin B1 intake. The results of the restricted cubic spline showed that vitamin B1 intake was nonlinearly associated with hypertensi...