MOF-modulated Fe3O4 Composited Au Nanoparticles for Antibacterial Wound Healing via Synergistic POD-like Nanozymatic Catalysis

作者：Chuan Liu, Xuanping Zhao, Zichao Wang, Yingyuan Zhao, Ruifang Li, Xuyang Chen, Hong Chen, Mengna Wan, Xueqin Wang · 发表于：Research Square · 年份：2023 · DOI：10.21203/rs.3.rs-3295697/v1 · 研究领域：Advanced Nanomaterials in Catalysis、Nanoplatforms for cancer theranostics、Graphene and Nanomaterials Applications

Abstract Bacterial-induced wound infection and healing difficulty severely threat people’s health and lives nowadays. Although traditional antibiotic treatment provides an effective strategy to defeat pathogenic bacteria, prolonged use and overuse of antibiotics cause the bacterium evolution with antibiotic resistance. Herein, we report an innovative hybrid nanozyme independent of antibiotics used for antimicrobial wound healing, which is constructed with ultrasmall Au NPs via in-situ growth on metal-organic framework (MOF) stabilized Fe 3 O 4 NPs (Fe 3 O 4 @MOF@Au NPs, FMA NPs). The results showed that the fabricated hybrid nanozyme displayed synergistic peroxidase (POD)-like activities, and generated a remarkable level of hydroxyl radicals (·OH) when assisted with a low dose of H 2 O 2 . Furthermore, the results showed that the hybrid FMA nanozymes exhibited excellent biocompatibility and favourable antibacterial performances against both Gram-negative Escherichia coli (E. coli) and Gram-positive ( S. aureus ) bacteria. Furthermore, animal experiments indicated that the hybrid nanozyme could availably promote wound repair employing satisfied biosafety. Therefore, this present study demonstrates that the fabricated hybrid nanozyme is a prospective alternative for bacteria infected wound healing, which has showed great potential for achieving non-poisonous wound repair healing in future clinical antimicrobial therapy.