Manipulating critical memory periods to treat psychiatry disorders

作者：Jiahui Deng, Xiao Lin, Yongbo Zheng, Sizhen Su, Xiaoxing Liu, Kai Yuan, Le Shi, Yanping Bao, Lin Lü · 发表于：中国科学通报：英文版 · 年份：2023 · DOI：10.1016/j.scib.2023.08.050 · 被引用次数：14 · 研究领域：Memory and Neural Mechanisms、Treatment of Major Depression、Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The persistence of pathological memory is the basis of several psychiatric disorders. Memory retrieval induces "reconsolidation", a time interval during which the original memory becomes labile and destabilized. Time- and retrieval-dependent processes and memory reconsolidation are critical periods for memory interference. Modulating memory reconsolidation has received considerable research attention as a treatment protocol for several psychiatric conditions such as posttraumatic stress disorder, addiction, anxiety, and trauma-related disorders. This specific time window provides an opportunity for intervention regarding mental diseases. This article reviews the effect of modulating memory reconsolidation using behavioral-, brain stimulation-, and pharmacological-based interventions, which may help bridge the gap between intervention in laboratories and application in clinical practice. The potential advantages, limitations, challenges, and opportunities for memory reconsolidation manipulations were discussed.