Epidemiological characteristics of leukemia in China, 2005–2017: a log-linear regression and age-period-cohort analysis

作者：Kangqian Lin, Huaimiao Jia, Miao Cao, Tongtong Xu, Zuhai Chen, Xi Song, Yingfang Miao, Yao Teng, Chenxian Dong, Jianjiang Shao, Heng Guo, Yunhua Hu, Yizhong Yan · 发表于：BMC Public Health · 年份：2023 · DOI：10.1186/s12889-023-16226-1 · 被引用次数：31 · 研究领域：Acute Lymphoblastic Leukemia research、Acute Myeloid Leukemia Research、Childhood Cancer Survivors' Quality of Life

BACKGROUND: Leukemia is a threat to human health, and there are relatively few studies on the incidence, mortality and disease burden analysis of leukemia in China. This study aimed to analyze the incidence and mortality rates of leukemia in China from 2005 to 2017 and estimate their age-period-cohort effects, it is an important prerequisite for effective prevention and control of leukemia. METHODS: Leukemia incidence and mortality data from 2005 to 2017 were collected from the Chinese Cancer Registry Annual Report. Joinpoint regression model was used to estimate the average annual percentage change (AAPC) and annual percentage change (APC) response time trend. Age-period-cohort model was constructed to analyze the effects of age, period and cohort. RESULTS: The age-standardized incidence rate of leukemia was 4.54/100,000 from 2005 to 2017, showed an increasing trend with AAPC of 1.9% (95% CI: 1.3%, 2.5%). The age-standardized mortality rate was 2.91/100,000, showed an increasing trend from 2005 to 2012 with APC of 2.1% (95%CI: 0.4%, 3.9%) and then a decreasing trend from 2012 to 2017 with APC of -2.5% (95%CI: -5.3%, 0.3%). The age-standardized incidence (mortality) rates of leukemia were not only higher in males than that in females, but also increased more rapidly. The incidence of leukemia in rural areas was lower than in urban areas, but the AAPC was 2.2 times higher than urban areas. Children aged 0-4 years were at higher risk of leukemia. The risk of leukemia incidence ...