Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry

作者：Ghislaine Scélo, Carlos Arturo Torres-Duque, Jorge Fernando Maspero, Trung Nam Tran, Ruth Murray, Neil Martin, Andrew N Menzies-Gow, Mark J Hew, Matthew J. Peters, Peter G. Gibson, George Christoff, Todor A. Popov, Andréanne Côté, Céline Bergeron, Delbert R. Dorscheid, John Mark FitzGerald, Kenneth R. Chapman, Louis Philippe Boulet, Mohit Kumar Bhutani, Mohsen Sadatsafavi, Libardo Jiménez-Maldonado, Mauricio Durán-Silva, Bellanid Rodriguez, Carlos Andrés Celis-Preciado, Diana Jimena Cano-Rosales, Iván Solarte, Maria Jose Fernandez-Sanchez, Patricia Parada-Tovar, Anna von Bülow, Anne Sofie Bjerrum, Charlotte Suppli Ulrik, Karin Dahl Assing, Linda Makowska Rasmussen, Susanne Hansen, Alan Altraja, Arnaud Bourdin, Camille Taillé, Jérémy Charriot, Nicolás Roche, Andriana I. Papaioannou, Konstantinos Kostikas, Nikolaos G. Papadopoulos, Sundeep Salvi, Deirdre Long, Patrick D. Mitchell, Richard W. Costello, Concetta Sirena, Cristina Cardini, Enrico Marco Heffler, Francesca Puggioni, Giorgio Walter Canonica, Giuseppe Guida, Takashi Iwanaga, Mona Sulaiman Al-Ahmad, Désirée E. Larenas‐Linnemann, Ulises García, Piotr Kuna, João Fonseca, Riyad Omar Al-Lehebi, Mariko Siyue Koh, Chin Kook Rhee, Borja G. Cosío, Luis Pérez de Llano, Diahn-Warng Perng, Erick Wan-Chun Huang, Hao‐Chien Wang, Ming-Ju Tsai, Bassam Mahboub, Laila Ibraheem Jaber Salameh, D.A. Jackson, John Busby, Liam Gabriel Heaney, Paul Pfeffer, Amanda Grippen Goddard, Eileen Wang, Flavia Cecilia Lega Hoyte, Michael E. Wechsler, Nicholas Chapman, Rohit K. Katial, Victoria A. Carter, Lakmini Bulathsinhala, Neva Eleangovan, Con Ariti, Juntao Lyu, David Price, Celeste Michala Porsbjerg · 发表于：Annals of Allergy Asthma & Immunology · 年份：2023 · DOI：10.1016/j.anai.2023.08.021 · 被引用次数：91 · 研究领域：Asthma and respiratory diseases、Sinusitis and nasal conditions、Respiratory and Cough-Related Research

BACKGROUND: Investigation for the presence of asthma comorbidities is recommended by the Global Initiative for Asthma because their presence can complicate asthma management. OBJECTIVE: To understand the prevalence and pattern of comorbidities and multimorbidity in adults with severe asthma and their association with asthma-related outcomes. METHODS: This was a cross-sectional study using data from the International Severe Asthma Registry from 22 countries. A total of 30 comorbidities were identified and categorized a priori as any of the following: (1) potentially type 2-related comorbidities, (2) potentially oral corticosteroid (OCS)-related comorbidities, or (3) comorbidities mimicking or aggravating asthma. The association between comorbidities and asthma-related outcomes was investigated using multivariable models adjusted for country, age at enrollment, and sex (ie male or female). RESULTS: Of the 11,821 patients, 69%, 67%, and 55% had at least 1 potentially type 2-related, potentially OCS-related, or mimicking or aggravating comorbidities, respectively; 57% had 3 or more comorbidities, and 33% had comorbidities in all 3 categories. Patients with allergic rhinitis, nasal polyposis, and chronic rhinosinusitis experienced 1.12 (P = .003), 1.16 (P < .001), and 1.29 times (P < .001) more exacerbations per year, respectively, than those without. Patients with nasal polyposis and chronic rhinosinusitis were 40% and 46% more likely (P < .001), respectively, to have received lo...