Microbiota-Gut-Brain Axis Dysregulation in Alzheimer's Disease: Multi-Pathway Effects and Therapeutic Potential

作者：Linkai Qu, Yanwei Li, Fan Liu, Yimeng Fang, Jiaxuan He, Jiahui Ma, Ting Xu, Lei Wang, Pengyu Lei, Hao Dong, Libo Jin, Qinsi Yang, Wei Wu, Da Sun · 发表于：Aging and Disease · 年份：2023 · DOI：10.14336/ad.2023.0823-2 · 被引用次数：42 · 研究领域：Gut microbiota and health、Tryptophan and brain disorders

An essential regulator of neurodegenerative conditions like Alzheimer's disease (AD) is the gut microbiota. Alterations in intestinal permeability brought on by gut microbiota dysregulation encourage neuroinflammation, central immune dysregulation, and peripheral immunological dysregulation in AD, as well as hasten aberrant protein aggregation and neuronal death in the brain. However, it is unclear how the gut microbiota transmits information to the brain and how it influences brain cognition and function. In this review, we summarized the multiple pathways involved in the gut microbiome in AD and provided detailed treatment strategies based on the gut microbiome. Based on these observations, this review also discusses the problems, challenges, and strategies to address current therapeutic strategies.