Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry

作者：Giulio Francesco Romiti, Bernadette Corica, Marco Proietti, Davide Antonio Mei, Juliane Frydenlund, Arnaud Bisson, Giuseppe Boriani, Brian Olshansky, Yi‐Hsin Chan, Menno V. Huisman, Tze‐Fan Chao, Gregory Y.H. Lip, Dzifa Wosornu Abban, Nasser Abdul, Atilio Marcelo Abud, Fran Adams, Srinivas Addala, Pedro Adragão, Walter Ageno, Rajesh Aggarwal, Sergio Agosti, Piergiuseppe Agostoni, Francisco Aguilar, Julio Aguilar Linares, Luis Aguinaga, Jameel Ahmed, Allessandro Aiello, Paul Ainsworth, Jorge Roberto Aiub, Raed Al-Dallow, Lisa Alderson, Jorge Antonio Aldrete Velasco, Dimitrios Alexopoulos, Fernando Alfonso Manterola, Pareed Aliyar, David Alonso, Fernando Costa, José Amado, W. Amara, Mathieu Amelot, Nima Amjadi, Fabrizio Ammirati, Marianna Andrade, Nabil Andrawis, Giorgio Annoni, Gerardo Ansalone, M. Kevin Ariani, Juan Carlos Arias, Sebastien Arméro, Chander Arora, Muhammad Shakil Aslam, M. Asselman, Philippe Audouin, Charles Augenbraun, Şenay Aydın, Ivaneta Ayryanova, Emad F. Aziz, Luciano Marcelo Backes, Erik Badings, Ermentina Bagni, Seth Baker, Richard Bala, Antonio Baldi, Shigenobu Bando, Subhash Banerjee, Alan J. Bank, Gonzalo Barón‐Esquivias, Craig Barr, Maria Bartlett, Vanja Bašić Kes, Giovanni Baula, Steffen Behrens, Alan Bell, Raffaella Benedetti, Juan Benezet Mazuecos, Bouziane Benhalima, Jutta Bergler‐Klein, Jean-Baptiste Berneau, Richard A. Bernstein, Percy Berrospi, Sergio Berti, Andrea Berz, Elizabeth A. Best, Paulo Bettencourt, Robert Betzu, Ravi Bhagwat, Luna Bhatta, Francesco Biscione, Giovanni Bisignani, Toby Black, Michael J. Bloch, Stephen R. Bloom, Edwin Blumberg, Mario Bo, Ellen Bøhmer, Andreas Bollmann, Maria Grazia Bongiorni, Giuseppe Boriani, D.J. Boswijk, Jochen Bott, E. Bottacchi, Marica Bracic Kalan, Drew Bradman, D. H. Brautigam, Nicolas Breton, Paul J.A.M. Brouwers, Kevin F. Browne, Jordi Bruguera Cortada, Adriana Antonella Bruni, Claude Brunschwig, Hervé Buathier, Aurélie Buhl, John Bullinga, Jose Walter Cabrera, Alberto Caccavo, Shanglang Cai, Sarah Caine, Leonardo Calò, Valéria Calvi, Mauricio Camarillo Sánchez, Rui Candeias, Vincenzo Capuano, Alessandro Capucci, Ronald Caputo, Tatiana Cárdenas Rizo, Francisco Cardona, Francisco Darrieux, Yan Carlos Duarte Vera, Antonio Carolei, Susana Carreño, Paula Carvalho, Susanna Cary, Gavino Casu, Claudio Cavallini, Guillaume Cayla, Aldo Celentano, Tae‐Joon Cha, Kwang Soo, Jei Keon Chae, Kathrine Chalamidas, Krishnan Challappa, Sunil Prakash Chand, Harinath Chandrashekar, Ludovic Chartier, Kausik Chatterjee, Carlos Antero Chavez Ayala, Aamir Cheema, Amjad Cheema, Lin Chen, Shih‐Ann Chen, Jyh Hong Chen, Fu‐Tien Chiang, Francesco Chiarella, Lin Chih-Chan, Yong Keun Cho, Jong‐Il Choi, Dong Ju Choi, Guy Chouinard, Danny Hoi-Fan Chow, Dimitrios Chrysos, Г. А. Чумакова, Eduardo Julián José Roberto, Chuquiure Valenzuela, Nicoleta Cindea Nica, David J. Cislowski, Anthony Clay, Piers Clifford, Andrew Cohen, Michael N. Cohen, Serge Cohen, Furio Colivicchi, Rónán Collins, Paolo Colonna, Steve Compton, Derek Connolly, Alberto Conti, Gabriel Contreras Buenostro, Gregg Coodley, Martin Cooper, Julián Coronel, Giovanni Corso, Juan Cosı́n-Sales, Yves Cottin, John Covalesky, Aurel Cracan, Filippo Crea, Peter Crean, James Crenshaw, Tina Cullen, Harald Darius, Patrick Dary, Olivier Dascotte, Ira Dauber, Vicente Davalos, Ruth Davies, Gershan Davis, Jean‐Marc Davy, Mark Dayer, Marzia De Biasio, Silvana De Bonis, Raffaele De Caterina, Teresiano De Franceschi, Joris R. de Groot, José De Horta, Axel De La Briolle, Gilberto de la Peña Topete, Ângelo Amato Vicenzo de Paola, Weimar de Souza, Anne de Veer, Luc De Wolf, Eric Decoulx, Sasalu Deepak, Pascal Defaye, Freddy Del‐Carpio Munoz, Diana Delić-Brkljačić, N. Joseph Deumite, Silvia Di Legge, Igor Diemberger, Denise Dietz, Pedro Dionísio, Qiang Dong, Fabio Rossi dos Santos, Elena Dotcheva, Rami Doukky, Anthony D’Souza, Simon W Dubrey, Xavier Ducrocq, Dmitry Dupljakov, Mauricio Duque, Dipankar Dutta, Nathalie Duvilla, A. Duygun, Rainer Dziewas, Charles B. Eaton, William Eaves, Lisa Ehrlich, Sabine Eichinger-Hasenauer, Steven Eisenberg, Adnan El Jabali, Mahfouz El Shahawy, Mauro Esteves Hernandes, Ana Etxeberria Izal, Rudolph Evonich, Oksana Evseeva, Andrey Ezhov, Raed Fahmy, Quan Fang, Ramin Farsad, Laurent Fauchier, Stefano Favale, Maxime Fayard, José Luis Fedele, Francesco Fedele, Olga Fedorishina, Steven R. Fera, Luís Gustavo Gomes Ferreira, Jorge Ferreira, Claudio Ferri, Anna Ferrier, Hugo Ferro, Alexandra Vanessa Finsen, Brian First, Stuart G. Fischer, Catarina Fonseca, Luísa Fonseca Almeida, Steven Forman, Brad Frandsen, William J. French, Keith Friedman, Athena Friese, Ana Gabriela Fruntelata, Shigeru Fujii, Stefano Fumagalli, Marta Fundamenski, Yutaka Furukawa, M. Gabelmann, Nashwa Gabra, Niels Gadsbøll, Michel Galinier, Anders Gammelgaard, Priya Ganeshkumar, Christopher Gans, Antonio Garcia Quintana, Olivier Gartenlaub, Achille Gaspardone, Conrad Genz, F. Georger, Jean‐Louis Georges, Steven Georgeson, Evaldas Giedrimas, Mariusz Gierba, I. Ortega, Eve Gillespie, Alberto Giniger, Michael Giudici, Alexandros Gkotsis, Taya V. Glotzer, Joachim Gmehling, Jacek Gniot, Peter Goethals, Seth Goldbarg, Ronald Goldberg, Britta Goldmann, Golitsyn Sp, Sílvia Gómez, Juan Gomez Mesa, Vicente Bertomeu‐González, J A González Hermosillo, Víctor Manuel González López, Hervé Gorka, Charles C. Gornick, Diana A. Gorog, Venkat Gottipaty, Pascal Goube, Ioannis Goudevenos, Brett Graham, G. Stephen Greer, Uwe Gremmler, Paul Grena, Martin Grond, Edoardo Gronda, Gerian Grönefeld, Xiang Gu, Ivett Guadalupe Torres Torres, Gabriele Guardigli, Carolina Guevara, Alexandre Guignier, Michele Massimo Gulizia, Michael Gumbley, Albrecht Günther, Andrew C.T. Ha, Georgios Hahalis, Joseph Hakas, Christian Hall, Bing Han, Seongwook Han, Joe Hargrove, David Hargroves, Kenneth B. Harris, Tetsuya Haruna, Emil Hayek, Jeff S. Healey, Steven Hearne, Michael Heffernan, Geir Heggelund, J. A. Heijmeriks, Maarten Hemels, Ivo A. Hendriks, Sam Henein, Sung‐Ho Her, Paul Hermany, Jorge Eduardo Hernández-del Río, Yorihiko Higashino, Michael D. Hill, Tetsuo Hisadome, Eiji Hishida, E Hoffer, Matthew Hoghton, Kui Hong, Suk Keun Hong, Stevie Horbach, Masataka Horiuchi, Yinglong Hou, Jeff Hsing, Chi-Hung Huang, David S. Huckins, Kathy Hughes, A. Huizinga, Elise L. Hulsman, Kuo‐Chun Hung, Gyo‐Seung Hwang, Margaret Ikpoh, Davide Imberti, Hüseyin İnce, Ciro Indolfi, Shujiro Inoue, Didier Irles, Harukazu Iseki, C. Noah Israel, Bruce Iteld, Venkat Iyer, Ewart Jackson-Voyzey, Naseem Jaffrani, Frank Jäger, Martin James, Sung-Won Jang, Nicolás Jaramillo, Nabil Jarmukli, Robert Jeanfreau, Ronald D. Jenkins, Carlos Jerjes Sánchez, Javier Jiménez, Robert Jobe, Tomas Joen-Jakobsen, Nicholas Jones, José Carlos Moura Jorge, Bernard Jouve, Byung Chun Jung, Kyung Tae Jung, Werner Jung, Mikhail Kachkovskiy, Krystallenia Kafkala, Larisa Kalinina, Bernd Kallmünzer, Farzan Kamali, Takehiro Kamo, Priit Kampus, Hisham E. Kashou, Andreas Kastrup, Apostolos Katsivas, Elizabeth S. Kaufman, Kazuya Kawai, Kenji Kawajiri, John F. Kazmierski, Phil Keeling, José Francisco Kerr Saraiva, Г. Г. Кетова, Ajit S Khaira, А. В. Хрипун, Doo‐Il Kim, Young‐Hoon Kim, Nam Ho Kim, Dae-Kyeong Kim, Jeong‐Su Kim, June Soo Kim, Ki Seok Kim, Jin‐Bae Kim, Elena Kinova, Alexander Klein, James J. Kmetzo, G. Larsen Kneller, Aleksandar Knežević, Angela S. Koh, Shunichi Koide, Αναστάσιος Κόλλιας, Johan Kooistra, Jay Koons, Martin Koschutnik, William J. Kostis, Dragan Kovačić, Jacek Kowalczyk, Natalya Koziolova, Peter Kraft, Johannes A. Kragten, Mori J. Krantz, Lars Udo Krause, Boudewijn J. Krenning, F. Krikke, Z. Kromhout, Waldemar Krysiak, Priya Kumar, Thomas Kümler, Malte Kuniss, Jen‐Yuan Kuo, Achim Küppers, Karla Kurrelmeyer, Choong Hwan Kwak, Bénédicte Laboulle, Arthur J. Labovitz, Wen Ter Lai, Andy Lam, Yat Yin Lam, Fernando Lanas Zanetti, Charles Landau, Giancarlo Landini, Estêvão Lanna Figueiredo, Torben Bjerregaard Larsen, Karine Lavandier, Jessica LeBlanc, Moon‐Hyoung Lee, Chang‐Hoon Lee, John J. Lehman, Ana Lúcia Leitão, Nicolas Lellouche, Małgorzata Lelonek, Radosław Lenarczyk, Timo Lenderink, Salvador León González, Peter Leong‐Sit, Matthias Leschke, Nicolas Ley, Zhanquan Li, Xiaodong Li, Weihua Li, Xiaoming Li, Christhoh Lichy, Ira Lieber, Ramon Horacio Limon Rodriguez, Hailong Lin, Gregory Y.H. Lip, Feng Liu, Hengliang Liu, Guillermo Llamas Esperón, Nassip Llerena Navarro, Eric Lo, Sergiy Lokshyn, Amador López, José López‐Sendón, Adalberto Menezes Lorga Filho, Richard S. Lorraine, Carlos Luengas, Robert Luke, Ming Luo, Steven Lupovitch, Philippe Lyrer, Changsheng Ma, Genshan Ma, Irene Madariaga, Koji Maeno, Dominique Magnin, Gustavo Maid, Sumeet K. Mainigi, Konstantinos Makaritsis, Rohit Malhotra, Rickey Manning, Athanasios Manolis, Helard Andrés Manrique Hurtado, Ioannis Mantas, Fernando Manzur Jattin, Vicky Maqueda, Niccolò Marchionni, Francisco Marin Ortuno, Antonio Martín Santana, Jorge Martinez, Petra Maskova, Norberto Matadamas Hernández, Katsuhiro Matsuda, Tillmann Maurer, Ciro Mauro, Erik May, Nolan Mayer, J. Andrew McClure, Terry McCormack, William C. McGarity, Hugh McIntyre, Brent McLaurin, Feliz Alvaro Medina Palomino, Francesco Melandri, Hiroshi Meno, D. W. Menzies, Marco Mercader, Christian Meyer, Beat J. 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Neykova, Ricardo Nicolás Miguel, George Nijmeh, Alexey Nizov, Rodrigo Noronha Campos, Janko Szavits Nossan, Tatiana Novikova, Ewa Nowalany-Kozielska, Emmanuel Nsah, Juan Carlos Núñez Fragoso, Svetlana Nurgalieva, Dieter Nuyens, Ole Nyvad, Manuel Odin de Los Rios Ibarra, Philip J. O’Donnell, Martin O’Donnell, Seil Oh, Yong‐Seog Oh, Dong‐Jin Oh, Gilles O’Hara, Kostas N. Oikonomou, Claudia Olivares, Richard Oliver, Rafael Olvera Ruíz, Christoforos Olympios, Anna omaszuk-Kazberuk, Joaquín Osca Asensi, eena Padayattil jose, Francisco Gerardo Padilla Padilla, Victoria Padilla Rios, Giuseppe Pajes, Shekhar Pandey, Gaetano Paparella, F Parı́s, Hyung Wook Park, Jong Sung Park, Fragkiskos Parthenakis, Enrico Passamonti, Rajesh Patel, Jaydutt Patel, Mehool Patel, Janice Patrick, Ricardo Pavón Jiménez, Analía Paz, Vittorio Pengo, William H. Pentz, Beatriz Pérez, Alma Minerva Pérez Ríos, Alejandro Pérez-Cabezas, Richard Perlman, Viktor Peršić, Francesco Perticone, Terri K. 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Roberts, Ignacio Rodríguez Briones, Aldo Edwin Rodriguez Escudero, Carlos Pascual, Mark Roman, Francesco Romeo, Eelko Ronner, Jean-François Roux, Nadezda Rozkova, Miroslav Rubáček, Frank Rubalcava, Andrea M. Russo, Matthieu Pierre Rutgers, Karin Rybak, Samir M. Said, Tamotsu Sakamoto, Abraham Salacata, Adrien Salem, Rafael Salguero‐Bodes, Marco A. Saltzman, Alessandro Salvioni, Gregorio Sánchez Vallejo, Marcelo Sanmartín Fernández, Wladmir Faustino Saporito, Kesari Sarikonda, Taishi Sasaoka, Hamdi Sati, Irina Savelieva, Pierre-Jean Scala, Peter D. Schellinger, Carlos Scherr, Lisa Schmitz, Karl-Heinz Schmitz, Bettina Schmitz, Teresa Schnabel, Steffen Schnupp, Peter Schoeniger, Norbert Schön, Peter Schwimmbeck, Clare Seamark, Greg Searles, Karlheinz Seidl, Barry Seidman, Jaroslaw Sek, Lakshmanan Sekaran, Carlo Serrati, Neerav Shah, Vinay Shah, Anil Shah, Shujahat Shah, Vijay K. Sharma, Louise Shaw, Khalid H. Sheikh, Naruhito Shimizu, Hideki Shimomura, Dong‐Gu Shin, Eun‐Seok Shin, Junya Shite, Gerolamo Sibilio, Frank L. Silver, Iveta Sime, Tim Simmers, Narendra Singh, Peter Siostrzonek, Didier Smadja, David W. Smith, Marcelo Snitman, Dario Sobral Filho, Hassan Soda, Carl Sofley, Adam Sokal, Yannie Soo Oi Yan, Rodolfo Sotolongo, Olga Ferreira de Souza, Jon Arne Sparby, Jindřich Špinar, David Sprigings, Alex C. Spyropoulos, Dimitrios Stakos, Clemens Steinwender, Georgios Stergiou, Ian G. Stiell, Marcus F. Stoddard, Anastas Stoikov, Witold Streb, Ioannis Stylıadis, Guohai Su, Xi Su, Wanda Sudnik, Kai Sukles, Xiaofei Sun, H. Swart, Janko Szavits-Nossan, Jens Taggeselle, Yuichiro Takagi, Amrit Takhar, Angelika Tamm, Katsumi Tanaka, Tanyanan Tanawuttiwat, Sherman Tang, Aylmer Tang, Giovanni Tarsi, Tiziana Tassinari, Ashis Tayal, Muzahir H. Tayebjee, Jurriën M. ten Berg, Dan Tesloianu, Salem H.K. The, Dierk Thomas, Serge Timsit, Tetsuya Tobaru, Andrzej Tomasik, Mikhail Torosoff, Emmanuel Touzé, Elina Trendafilova, W. Kevin Tsai, Hung‐Fat Tse, Hiroshi Tsutsui, Tian Ming Tu, Ype S. Tuininga, Minang Turakhia, Samir Turk, Wayne Turner, Arnljot Tveit, Richard Tytus, Carlos Augusto Araújo Valadão, P. F. M. M. van Bergen, Philippe van de Borne, Bettina Berg, C. van der Zwaan, Martijn van Eck, Peter Vanacker, Dimo Vasilev, Vasileios Vasilikos, Maxim Vasilyev, Srikar Veerareddy, Mario Vega Miño, Paolo Verdecchia, Francesco Versaci, E. G. Vester, Hubert Vial, Jason Victory, Alejandro Villamil, Marc Vincent, Anthony Vlastaris, Jürgen vom Dahl, Kishor Vora, Robert B. Vranian, Phil Wakefield, Ningfu Wang, Ming‐Sheng Wang, Xinhua Wang, Feng Wang, Tian Wang, Alberta L. Warner, Kouki Watanabe, Jeanne Wei, Christian Weimar, Stanislav Weiner, R Weinrich, Ming‐Shien Wen, Marcus Wiemer, P Wiggers, Andreas Wilke, David Williams, Marcus L. Williams, Bernhard Witzenbichler, Brian Y L Wong, Ka Sing Wong, Beata Wożakowska−Kapłon, Shulin Wu, Richard C. Wu, Silke Wunderlich, Nell Wyatt, John V. Wylie, Yong Xu, Xiangdong Xu, Hiroki Yamanoue, Takeshi Yamashita, Ping Yan, Tianlun Yang, Jing Yao, Kuo‐Ho Yeh, Wei Hsian Yin, Yoto Yotov, Ralf Zahn, Stuart Zarich, С. А. Зенин, Elisabeth Louise Zeuthen, Huanyi Zhang, Donghui Zhang, Xingwei Zhang, Ping Zhang, Jun Zhang, Shui Ping Zhao, Yujie Zhao, Zhichen Zhao, Zheng Yang, Jing Zhou, Sergio Zimmermann, Andrea Zini, Steven Zizzo, Wenxia Zong, L. Steven Zukerman · 发表于：EClinicalMedicine · 年份：2023 · DOI：10.1016/j.eclinm.2023.102039 · 被引用次数：44 · 研究领域：Atrial Fibrillation Management and Outcomes、Vitamin K Research Studies、Folate and B Vitamins Research

Background: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. Methods: From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. Findings: 34,421 patients were included (70.0 ± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients...