Association of nocturia of self-report with estimated glomerular filtration rate: a cross-sectional study from the NHANES 2005–2018

作者：Jianling Song, Ben Ke, Xiangdong Fang · 发表于：Scientific Reports · 年份：2023 · DOI：10.1038/s41598-023-39448-0 · 被引用次数：6 · 研究领域：Urinary Bladder and Prostate Research、Blood Pressure and Hypertension Studies、Chronic Kidney Disease and Diabetes

Abstract Nocturia is a manifestation of systemic diseases, in which chronic kidney disease (CKD) is an independent predictor of nocturia due to its osmotic diuretic mechanism. However, to our knowledge, previous studies have not examined the association between nocturia and estimated glomerular filtration rate (eGFR). The purpose of this study was to assess the association between nocturia exposure and eGFR in the general US population. This study presents a cross-sectional analysis of the general US population enrolled in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. To account for potential confounding factors, linear regression analysis was conducted to investigate the association between nocturia and eGFR. Stratified analyses and interaction tests were employed to examine the variables of interest. Additionally, sensitivity analyses were conducted across diverse populations. A total of 12,265 individuals were included in the study. After controlling for confounding factors, the results of the linear regression analysis indicated that a single increase in nocturnal voiding frequency was associated with a decrease in eGFR by 2.0 mL/min/1.73 m 2 . In comparison to individuals with a nocturnal urinary frequency of 0, those who voided 1, 2, 3, 4, and ≥ 5 times at night experienced a decrease in eGFR by 3.1, 5.4, 6.4, 8.6 and 4.0 mL/min/1.73 m 2 , respectively. Nocturia was found to be associated with a decreased eGFR of 4 mL/min/1.73 m 2 when...