Biomimetic Nanozyme-Decorated Hydrogels with H 2 O 2 -Activated Oxygenation for Modulating Immune Microenvironment in Diabetic Wound

作者：Yüe Zhao, Yüe Zhao, Dongdong Wang, Tianwei Qian, Junmin Zhang, Zuhao Li, Qiaoyun Gong, Xiangzhong Ren, Yanli Zhao, Yanli Zhao · 发表于：ACS Nano · 年份：2023 · DOI：10.1021/acsnano.3c03761 · 被引用次数：159 · 研究领域：Diabetic Foot Ulcer Assessment and Management、Wound Healing and Treatments、Nanoplatforms for cancer theranostics

Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels are promising systems for DFU-based wound management, their effectiveness is often hindered by the immune response and hostile wound microenvironment associated with the uncontrollable accumulation of reactive oxygen species and hypoxia. Here, we develop a therapeutic wound dressing using a biomimetic hydrogel system with the decoration of catalase-mimic nanozyme, namely, MnCoO@PDA/CPH. The hydrogel can be designed to match the mechanical and electrical cues of skins simultaneously with H 2 O 2 -activated oxygenation ability. As a proof of concept, DFU-based rat models are created to validate the therapeutic efficacy of the MnCoO@PDA/CPH hydrogel in vivo. The results indicate that the developed hydrogel can promote DFU healing and improve the quality of the healed wound as featured by alleviated proinflammatory, increased re-epithelialization, highly ordered collagen deposition, and functional blood vessel growth.