Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study

作者：Mie Rizig, Sara Bandrés‐Ciga, Mary B. Makarious, Oluwadamilola Omolara Ojo, Peter Wild Crea, Oladunni Abiodun, Kristin S. Levine, Sani Abubakar, Charles Achoru, Dan Vitale, Olaleye Akinmola Adeniji, Osigwe Paul Agabi, Mathew J. Koretsky, Uchechi Agulanna, Deborah A Hall, Rufus Akinyemi, Tao Xie, Mohammed Wulgo Ali, Ejaz A. Shamim, Ifeyinwa Ani-Osheku, Mahesh Padmanaban, Ohwotemu Arigbodi, David G. Standaert, Abiodun Hamzat Bello, Marissa N. Dean, Cyril Oshomah Erameh, Inas Elsayed, Temitope Farombi, Olaitan Okunoye, Bimbo Fawale, Kimberley J. Billingsley, Frank Aiwansoba Imarhiagbe, Pilar Álvarez Jerez, Emmanuel Uzodinma Iwuozo, Breeana Baker, Morenikeji Adeyoyin Komolafe, Laksh Malik, Paul Nwani, Kensuke Daida, Ernest Okwundu Nwazor, Abigail Miano‐Burkhardt, Yakub Wilberforce Nyandaiti, Zih‐Hua Fang, Yahaya Obiabo, Jillian H. Kluss, Olanike Odeniyi, Dena G. Hernandez, Francis Ehidiamen Odiase, Nahid Tayebi, FI Ojini, Ellen Sidranksy, Gerald Onwuegbuzie, Andrea D'Souza, Godwin Osaigbovo, Bahafta A. Berhe, Nosakhare Osemwegie, Xylena Reed, Olajumoke Oshinaike, Hampton L. Leonard, Folajimi Morenikeji Otubogun, Chelsea X. Alvarado, Shyngle Oyakhire, Simon Izuchukwu Ozomma, Sarah Samuel, Funmilola Tolulope Taiwo, Kolawole Wasiu Wahab, Yusuf Zubair, Hirotaka Iwaki, Jonggeol Jeffrey Kim, Huw R. Morris, John Hardy, Mike A. Nalls, Karl Heilbron, Lucy Norcliffe‐Kaufmann, Njideka Okubadejo, Njideka Okubadejo, Oluwadamilola Ojo, Oladunni Abiodun, Charles Achoru, Osigwe Agabi, Uchechi Agulanna, Rufus Akinyemi, Mohammed Ali, Ifeyinwa Ani-Osheku, Ohwotemu Arigbodi, Abiodun Bello, Cyril Erameh, Temitope Farombi, Michael Fawale, Frank Aiwansoba Imarhiagbe, Emmanuel Uzodinma Iwuozo, Morenikeji Komolafe, Paul Nwani, Ernest Nwazor, Yakub Wilberforce Nyandaiti, Yahaya Obiabo, Olanike Odeniyi, Francis Odiase, Francis Ojini, Gerald Onwuegbuzie, Godwin Osaigbovo, Nosakhare Osemwegie, Olajumoke Oshinaike, Folajimi Otubogun, Shyngle Oyakhire, Simon Izuchukwu Ozomma, Sarah Samuel, Funmilola Taiwo, Kolawole Wahab, Yusuf Zubair, Daniel Gams Massi, Eric Gueumekane Bila Lamou, Leonard Njamnshi Nfor, Mélanie Annick Magnerou, Yannick Fogang Fogoum, Ali Shalash, Hassan El-FawaI, Eman M. Khedr, Gharib Fawi, Mohamed A. Eltantawi, Mohamed Salama, Shaimaa El-Jaafary, Sharifa Hamed, Abenet Tafesse Mengesha, Biniyam Alemayehu Ayele, Dereje Melka Oda, Yared Zenebe Zewde, Yohanesse Debebe Gelan, Albert AkpaIu, Augustina Charway‐Felli, Fred Stephen Sarfo, Patrick Adjei, Vida Obese, Abdoulaye Bocoum, Abdou Koïta, Cheick Oumar Guinto, Toumany Coulibaly, Youssoufa M. Maiga, Zaynab Kone, Abiodun Bell, Osigwe Agabi, Akintunde Adebowale, John E. Akpekpe, Alagoma lyagba, Ali Mohammed Wulgo, Ifeyinwa Ani-Osheku, Babawale Arabambi, Charles Achoru, Christian Agu, Cyril Erameh, Emmanuel Iwuozo, Ernest Nwazor, Michael Fawale, Folajimi Otubogun, Francis Odiase, Franklin Okechukwu Dike, Ismail Ogunbayode Ishola, Kolawole Wahab, Kehinde Emmanuel Abiodun, Morenikeji Komolafe, Njideka Okubadejo, Njideka Okubadejo, Yahaya Obiabo, Ohwotemu Arigbodi, Olajumoke Oshinaike, Nosakhare Osemwegie, Oluchi Stella Ekenze, Oluwadamilola Ojo, Paul Agabi Osigwe, Paul Nwani, Salisu Abdullahi Balarabe, Sani Abubakar, Uduak Effiong Williams, Oladunni Abiodun, Yusuf Zubair, Maouly Fall, Alassane Mamadou Diop, Ewodo Touna Hilaire Dominique, Andre Mochan, Girish Modi, Saiesha Dindayal, Eman Ali Awadelkareem, Inas Elsayed, Maha Dahawi, Mosab Ali Awadelkareem, Sarah Misbah, Brighton Mushengez, Henrika Kimambo, Leonard Msango, Philip Babatunde Adebayo, Kigocha OKeng, Marieke Diekker, Sarah Urassa, Riadh Gouider, Mouna Ben Djebara, Amina Gargouri, Imen Kacem, Amina Nasri, Saloua Mrabet, Ikram Sghaier, Imen Mkada, Masharip Atadzhanov, Lorraine Chishimba, Mie Rizig, Fatumah Jama, Olaitan Okunoye, John Hardy, Henry Houlden, Andrew Singleton, Andrew Singleton, Mike Nalls, Ejaz Shamim, Cabell Jonas, Jared Williamson, Deborah A. Hall, Marc Rosenbaum, Staci Davis, Marissa Dean, Candace Cromer, Jenna Smith, Lauren Ruffrage, J. David Richardson, Rebeka Sipma, Tao Xie, Manesh Padmanaban, Natalie Warren, Tomas Mercado, Elizabeth A. Disbrow, Brian Chauppeta, Fermine Thomas-Dean, Jamie Toms, Katelyn Lofton, Ashley Rawls, Kyle Rizer, Nieci Black, Justin Solle, Alyssa O'Grady, Todd Sherer, Brian Fiske, Cornelis Blauwendraat, Henry Houlden, Andrew Singleton, Andrew Singleton, Njideka Ulunma Okubadejo, Njideka Ulunma Okubadejo, A. Nazlı Başak, Ai Huey Tan, Alastair John Noyce, Albert Kwaku Akpalu, Alberto J. Espay, Alejandro Martínez-Carrasco, Alex Medina, Alexander A. Zimprich, Alexis Brice, Altynay Karimova, Alvaro Hernández‐Flores, Alyssa O'Grady, Anastasia Illarionova, Andrea Quattrone, Andrew B Singleton, Andrew B Singleton, Andrew K. Sobering, Ángel Viñuela, Arinola Sanyaolu, Artur Francisco Schumacher Schuh, Asha Kishore, Azlina Ahmad‐Annuar, Bashayer Al Mubarak, Beisha Tang, Benjamin Pizarro Galleguillos, Beomseok Jeon, Bernadette Siddiqi, Bradford H. Casey, Brian Fiske, Brit Mollenhauer, Cabell Jonas, Camille Carroll, Carlos Roberto de Mello Rieder, Caroline B. Pantazis, Charisse Comart, Chin-Hsien Lin, Christine Klein, Claire Bale, Claire E. Shepherd, Claire Wegel, Cornelis Blauwendraat, Dan Vitale, Daniel Martínez-Ramírez, Deborah Hall, Dena Hernandez, Divya KP, Duan Nguyen, Edward A. Fon, Efthymios Dadiotis, Ejaz Shamim, Ekemini Riley, Е. А. Яковенко, Ellie Stafford, Emilia Mabel Gatto, Enza Maria Valente, Eva‐Juliane Vollstedt, Faraz Faghri, Gençer Genç, Georgia Xiromerisiou, Georgios Hadjigorgiou, Germaine Hiu-Fai Chan, Gonzálo Arboleda, Gulnaz Kaishibayeva, Günter U. Höglinger, Hampton Leonard, Harutyun Madoev, Henry Houlden, Hirotaka Iwaki, Honglei Chen, Hsiu-Chuan Wu, Huifang Shang, Huw R Morris, Ignacio F. Mata, Ignacio Juan Keller Sarmiento, Ioannis E. Dagklis, Ioannis Tarnanas, Jan Olav Aasly, Janet Hoenicka, Jared Williamson, Jean‐Christophe Corvol, Jia Nee Foo, Jifeng Guo, Johanna Junker, John Hardy, Jonathan Ambrose Carr, Jonggeol Jeff Kim, Jorge Orozco, Joseph Jankovic, Joshua M Shulman, Julie Hunter, Justin C. Solle, Kaileigh Murphy, Karen Nuytemans, Karl Kieburtz, Katja Lohmann, KENNETH L. MAREK, Kin Ying Mok, Kishore Raj Kumar, Kristin Levine, Lana M. Chahine, Lara Mariah Lange, Lasse Pihlstrøm, Laurel A. Screven, Leonidas Stefanis, Lisa M. Shulman, Luca Marsili, Lucilla Parnetti, Maggie McGuire Kuhl, Manabu Funayama, Manu Sharma, Manuela M. X. Tan, Marcelo Kauffman, Marcelo Miranda, María Leonor Bustamante, Maria Stamelou, Maria Teresa Periñan Tocino, Mario Cornejo‐Olivas, Marissa Dean, Marlene Jimenez del Rio, Mary B Makarious, Masharip Atadzhanov, Mathew Koretsky, Mayela Rodríguez‐Violante, Melina Ellis, Micol Avenali, Mie Rizig, Miguel E. Rentería, Miguel z Inca-Martines, Mike A. Nalls, Mohamed Ibrahim Norlinah, Mohamed Salama, Muhammad Umair, Nancy Ip, Naomi Louie, Nelson Yuk-Fai Cheung, Niccolò Emanuele Mencacci, Nicholas Wood, Nigel M. Williams, Njideka Okubadejo, Njideka Okubadejo, Nobutaka Hattori, Nor Azian Abdul Murad, Norlinah Mohamed Ibrahim, Olaitan Okunoye, Oluwadamilola Ojo, Oury Monchi, Özgür Öztop Çakmak, Patricio Öztop Çakmak Öztop Çakmak, Patrick Alfryn Lewis, Pau Pástor, Paula Reyes‐Pérez, Paula Saffie Awad, Pedro Chaná, Phillip Chan, Pin‐Jui Kung, Piu Chan, Pramod Kumar Pal, Prashanth Lingappa Kukkle, Rajeev Ojha, Rauan Kaiyrzhanov, Rejko Krüger, Rim Amouri, Rimona Sharon Weil, Roopa Rajan, Roy N. Alcalay, Ruey-Meei Wu, Rupam Borgohain, Samia Ben Sassi, Samson G. Khachatryan, Sara Bandres-Ciga, Sarah El-Sadig, Serena Shuo Wu, Sergio Groppa, Shahrul Azmin, Shen‐Yang Lim, Shoaib Ur-Rehman, Sibel Ertan, Simon Stott, Simona Jasaitye, Sohini Chowdhury, Sonya B. Dumanis, Soraya Bardien, Steven J Lubbe, Sulev Kõks, Sumit Dey, Tao Xie, Tatiana Foroud, Ted Fon, Thomas Beach, Thomas Gasser, Tim Anderson, Toan Nguyen, Todd Sherer, Tommaso Schirinzi, Tomotaka Shiraishi, Toni L. Pitcher, Vida Obese, Vítor Tumas, Wael M.Y. Mohamed, Walaa A. Kamel, Wei Feng Luo, Xiaopu Zhou, Yared Zenebe Zewde, Yeajin Song, Yi Wen, Yih‐Ru Wu, Yun Joong Kim, Zaruhi Tavadyan, Zih‐Hua Fang · 发表于：The Lancet Neurology · 年份：2023 · DOI：10.1016/s1474-4422(23)00283-1 · 被引用次数：165 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Lysosomal Storage Disorders Research、Neurological diseases and metabolism