Associations between modifiable risk factors and frailty: a Mendelian randomisation study

作者：Nan Zhang, Ziheng Jia, Tianshu Gu, Yi Zheng, Yunpeng Zhang, Wenhua Song, Ziliang Chen, Guangping Li, Guangping Li, Gary Tse, Tong Liu · 发表于：Journal of Epidemiology & Community Health · 年份：2023 · DOI：10.1136/jech-2023-220882 · 被引用次数：36 · 研究领域：Frailty in Older Adults、Genetic Associations and Epidemiology、Chronic Disease Management Strategies

BACKGROUND: Early identification of modifiable risk factors is essential for the prevention of frailty. This study aimed to explore the causal relationships between a spectrum of genetically predicted risk factors and frailty. METHODS: Univariable and multivariable Mendelian randomisation (MR) analyses were performed to explore the relationships between 22 potential risk factors and frailty, using summary genome-wide association statistics. Frailty was accessed by the frailty index. RESULTS: Genetic liability to coronary artery disease (CAD), type 2 diabetes mellitus (T2DM), ischaemic stroke, atrial fibrillation and regular smoking history, as well as genetically predicted 1-SD increase in body mass index, systolic blood pressure, diastolic blood pressure, low-density lipoprotein cholesterol, triglycerides, alcohol intake frequency and sleeplessness were significantly associated with increased risk of frailty (all p<0.001). In addition, there was a significant inverse association between genetically predicted college or university degree with risk of frailty (beta -0.474; 95% CI (-0.561 to -0.388); p<0.001), and a suggestive inverse association between high-density lipoprotein cholesterol level with risk of frailty (beta -0.032; 95% CI (-0.055 to -0.010); p=0.004). However, no significant causal associations were observed between coffee consumption, tea consumption, serum level of total testosterone, oestradiol, 25-hydroxyvitamin D, C reactive protein or moderate to vigorous ...